挫折应对自我监控探析

提高挫折应对质量,增强挫折承受能力,必须实现挫折应对自我监控,挫折应对自我监控包括自我监控知识,自我监控技能和自我监近体验,其中,自我监控技能分为：注意识别,评价,计划和调节,在挫折应地活动中,自我监控通过自我提问激活,从而对挫折应对过程（包括预先应对,事先应对和挫折应对）和挫折应对风格实施监控,挫折应对自我监控可以通过相应的训练得到改善。     

A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis

Chronic pancreatitis is a common inflammatory disease of the pancreas. Mutations in the genes encoding cationic trypsinogen (PRSS1) and the pancreatic secretory trypsin inhibitor (SPINK1) are associated with chronic pancreatitis. Because increased proteolytic activity owing to mutated PRSS1 enhances the risk for chronic pancreatitis, mutations in the gene encoding anionic trypsinogen (PRSS2) may also predispose to disease. Here we analyzed PRSS2 in individuals with chronic pancreatitis and controls and found, to our surprise, that a variant of codon 191 (G191R) is overrepresented in control subjects: G191R was present in 220/6,459 (3.4%) controls but in only 32/2,466 (1.3%) affected individuals (odds ratio 0.37; P = 1.1 x 10(-8)). Upon activation by enterokinase or trypsin, purified recombinant G191R protein showed a complete loss of trypsin activity owing to the introduction of a new tryptic cleavage site that renders the enzyme hypersensitive to autocatalytic proteolysis. In conclusion, the G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis.     

论创造性人才的培养与新时代德育

如何实施创新教育,培养创造性人才是当前教育改革的研究主题.探讨创造性人才的培养与德育之间的密切关系,认为培养学生的创造性也应成为新时代德育的新要求.