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1.
Thermochemical structures beneath Africa and the Pacific Ocean 总被引:2,自引:0,他引:2
Large low-velocity seismic anomalies have been detected in the Earth's lower mantle beneath Africa and the Pacific Ocean that are not easily explained by temperature variations alone. The African anomaly has been interpreted to be a northwest-southeast-trending structure with a sharp-edged linear, ridge-like morphology. The Pacific anomaly, on the other hand, appears to be more rounded in shape. Mantle models with heterogeneous composition have related these structures to dense thermochemical piles or superplumes. It has not been shown, however, that such models can lead to thermochemical structures that satisfy the geometrical constraints, as inferred from seismological observations. Here we present numerical models of thermochemical convection in a three-dimensional spherical geometry using plate velocities inferred for the past 119 million years. We show that Earth's subduction history can lead to thermochemical structures similar in shape to the observed large, lower-mantle velocity anomalies. We find that subduction history tends to focus dense material into a ridge-like pile beneath Africa and a relatively more-rounded pile under the Pacific Ocean, consistent with seismic observations. 相似文献
2.
Bateson P Barker D Clutton-Brock T Deb D D'Udine B Foley RA Gluckman P Godfrey K Kirkwood T Lahr MM McNamara J Metcalfe NB Monaghan P Spencer HG Sultan SE 《Nature》2004,430(6998):419-421
Many plants and animals are capable of developing in a variety of ways, forming characteristics that are well adapted to the environments in which they are likely to live. In adverse circumstances, for example, small size and slow metabolism can facilitate survival, whereas larger size and more rapid metabolism have advantages for reproductive success when resources are more abundant. Often these characteristics are induced in early life or are even set by cues to which their parents or grandparents were exposed. Individuals developmentally adapted to one environment may, however, be at risk when exposed to another when they are older. The biological evidence may be relevant to the understanding of human development and susceptibility to disease. As the nutritional state of many human mothers has improved around the world, the characteristics of their offspring--such as body size and metabolism--have also changed. Responsiveness to their mothers' condition before birth may generally prepare individuals so that they are best suited to the environment forecast by cues available in early life. Paradoxically, however, rapid improvements in nutrition and other environmental conditions may have damaging effects on the health of those people whose parents and grandparents lived in impoverished conditions. A fuller understanding of patterns of human plasticity in response to early nutrition and other environmental factors will have implications for the administration of public health. 相似文献
3.
Gamma-tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation. 总被引:31,自引:0,他引:31
gamma-Tubulin is a newly identified member of the tubulin family whose sequence is highly conserved from yeast to man. This minor microtubule protein is localized to the microtubule organizing centres and a mutation in the gene encoding it produces a microtubuleless mitotic arrest in the filamentous fungus Aspergillus nidulans. Here we investigate the in vivo function of gamma-tubulin in mammalian cells using a synthetic peptide to generate a polyclonal antibody that binds to a highly conserved segment of gamma-tubulin. After microinjection into cultured mammalian cells, immunofluorescence localization revealed that this antibody binds to native centrosomes at all phases of the cell cycle. In the presence of the gamma-tubulin antibody, microtubules fail to regrow into cytoplasmic arrays after depolymerization induced by nocodazole or cold. Furthermore, cells injected immediately before or during mitosis fail to assemble a functional spindle. Thus in vivo gamma-tubulin is required for microtubule nucleation throughout the mammalian cell cycle. 相似文献
4.
Jeltes T McNamara JM Hogervorst W Vassen W Krachmalnicoff V Schellekens M Perrin A Chang H Boiron D Aspect A Westbrook CI 《Nature》2007,445(7126):402-405
Fifty years ago, Hanbury Brown and Twiss (HBT) discovered photon bunching in light emitted by a chaotic source, highlighting the importance of two-photon correlations and stimulating the development of modern quantum optics. The quantum interpretation of bunching relies on the constructive interference between amplitudes involving two indistinguishable photons, and its additive character is intimately linked to the Bose nature of photons. Advances in atom cooling and detection have led to the observation and full characterization of the atomic analogue of the HBT effect with bosonic atoms. By contrast, fermions should reveal an antibunching effect (a tendency to avoid each other). Antibunching of fermions is associated with destructive two-particle interference, and is related to the Pauli principle forbidding more than one identical fermion to occupy the same quantum state. Here we report an experimental comparison of the fermionic and bosonic HBT effects in the same apparatus, using two different isotopes of helium: (3)He (a fermion) and 4He (a boson). Ordinary attractive or repulsive interactions between atoms are negligible; therefore, the contrasting bunching and antibunching behaviour that we observe can be fully attributed to the different quantum statistics of each atomic species. Our results show how atom-atom correlation measurements can be used to reveal details in the spatial density or momentum correlations in an atomic ensemble. They also enable the direct observation of phase effects linked to the quantum statistics of a many-body system, which may facilitate the study of more exotic situations. 相似文献
5.
Explaining the rise and maintenance of cooperation is central to our understanding of biological systems and human societies. When an individual's cooperativeness is used by other individuals as a choice criterion, there can be competition to be more generous than others, a situation called competitive altruism. The evolution of cooperation between non-relatives can then be driven by a positive feedback between increasing levels of cooperativeness and choosiness. Here we use evolutionary simulations to show that, in a situation where individuals have the opportunity to engage in repeated pairwise interactions, the equilibrium degree of cooperativeness depends critically on the amount of behavioural variation that is being maintained in the population by processes such as mutation. Because our model does not invoke complex mechanisms such as negotiation behaviour, it can be applied to a wide range of species. The results suggest an important role of lifespan in the evolution of cooperation. 相似文献
6.
McNamara BR Nulsen PE Wise MW Rafferty DA Carilli C Sarazin CL Blanton EL 《Nature》2005,433(7021):45-47
Most of the baryons in galaxy clusters reside between the galaxies in a hot, tenuous gas. The densest gas in their centres should cool and accrete onto giant central galaxies at rates of 10-1,000 solar masses per year. No viable repository for this gas, such as clouds or new stars, has been found. New X-ray observations, however, have revealed far less cooling below X-ray temperatures than expected, altering the previously accepted picture of cooling flows. As a result, most of the gas must be heated to and maintained at temperatures above approximately 2 keV (ref. 3). The most promising heating mechanism is powerful radio jets emanating from supermassive black holes in the central galaxies of clusters. Here we report the discovery of giant cavities and shock fronts in a distant (z = 0.22) cluster caused by an interaction between a radio source and the hot gas surrounding it. The energy involved is approximately 6 x 10(61) erg, the most powerful radio outburst known. This is enough energy to quench a cooling flow for several Gyr, and to provide approximately 1/3 keV per particle of heat to the surrounding cluster. 相似文献
7.
Maser RS Choudhury B Campbell PJ Feng B Wong KK Protopopov A O'Neil J Gutierrez A Ivanova E Perna I Lin E Mani V Jiang S McNamara K Zaghlul S Edkins S Stevens C Brennan C Martin ES Wiedemeyer R Kabbarah O Nogueira C Histen G Aster J Mansour M Duke V Foroni L Fielding AK Goldstone AH Rowe JM Wang YA Look AT Stratton MR Chin L Futreal PA DePinho RA 《Nature》2007,447(7147):966-971
Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the neoplastic transformation process. Here we engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mouse models in cancer gene discovery and the extent of cross-species overlap in cancer-associated copy number aberrations. Along with targeted re-sequencing, our comparative oncogenomic studies identified FBXW7 and PTEN to be commonly deleted both in murine lymphomas and in human T-cell acute lymphoblastic leukaemia/lymphoma (T-ALL). The murine cancers acquire widespread recurrent amplifications and deletions targeting loci syntenic to those not only in human T-ALL but also in diverse human haematopoietic, mesenchymal and epithelial tumours. These results indicate that murine and human tumours experience common biological processes driven by orthologous genetic events in their malignant evolution. The highly concordant nature of genomic events encourages the use of genomically unstable murine cancer models in the discovery of biological driver events in the human oncogenome. 相似文献
8.
LKB1 modulates lung cancer differentiation and metastasis 总被引:1,自引:0,他引:1
Ji H Ramsey MR Hayes DN Fan C McNamara K Kozlowski P Torrice C Wu MC Shimamura T Perera SA Liang MC Cai D Naumov GN Bao L Contreras CM Li D Chen L Krishnamurthy J Koivunen J Chirieac LR Padera RF Bronson RT Lindeman NI Christiani DC Lin X Shapiro GI Jänne PA Johnson BE Meyerson M Kwiatkowski DJ Castrillon DH Bardeesy N Sharpless NE Wong KK 《Nature》2007,448(7155):807-810
Germline mutation in serine/threonine kinase 11 (STK11, also called LKB1) results in Peutz-Jeghers syndrome, characterized by intestinal hamartomas and increased incidence of epithelial cancers. Although uncommon in most sporadic cancers, inactivating somatic mutations of LKB1 have been reported in primary human lung adenocarcinomas and derivative cell lines. Here we used a somatically activatable mutant Kras-driven model of mouse lung cancer to compare the role of Lkb1 to other tumour suppressors in lung cancer. Although Kras mutation cooperated with loss of p53 or Ink4a/Arf (also known as Cdkn2a) in this system, the strongest cooperation was seen with homozygous inactivation of Lkb1. Lkb1-deficient tumours demonstrated shorter latency, an expanded histological spectrum (adeno-, squamous and large-cell carcinoma) and more frequent metastasis compared to tumours lacking p53 or Ink4a/Arf. Pulmonary tumorigenesis was also accelerated by hemizygous inactivation of Lkb1. Consistent with these findings, inactivation of LKB1 was found in 34% and 19% of 144 analysed human lung adenocarcinomas and squamous cell carcinomas, respectively. Expression profiling in human lung cancer cell lines and mouse lung tumours identified a variety of metastasis-promoting genes, such as NEDD9, VEGFC and CD24, as targets of LKB1 repression in lung cancer. These studies establish LKB1 as a critical barrier to pulmonary tumorigenesis, controlling initiation, differentiation and metastasis. 相似文献
9.
Molecular emission from single-bubble sonoluminescence 总被引:5,自引:0,他引:5
Ultrasound can drive a single gas bubble in water into violent oscillation; as the bubble is compressed periodically, extremely short flashes of light (about 100 ps) are generated with clock-like regularity. This process, known as single-bubble sonoluminescence, gives rise to featureless continuum emission in water (from 200 to 800 nm, with increasing intensity into the ultraviolet). In contrast, the emission of light from clouds of cavitating bubbles at higher acoustic pressures (multi-bubble sonoluminescence) is dominated by atomic and molecular excited-state emission at much lower temperatures. These observations have spurred intense effort to uncover the origin of sonoluminescence and to generalize the conditions necessary for its creation. Here we report a series of polar aprotic liquids that generate very strong single-bubble sonoluminescence, during which emission from molecular excited states is observed. Previously, single-bubble sonoluminescence from liquids other than water has proved extremely elusive. Our results give direct proof of the existence of chemical reactions and the formation of molecular excited states during single-bubble cavitation, and provide a spectroscopic link between single- and multi-bubble sonoluminescence. 相似文献
10.
Development of anisotropic structure in the Earth's lower mantle by solid-state convection 总被引:2,自引:0,他引:2
Seismological observations reveal highly anisotropic patches at the bottom of the Earth's lower mantle, whereas the bulk of the mantle has been observed to be largely isotropic. These patches have been interpreted to correspond to areas where subduction has taken place in the past or to areas where mantle plumes are upwelling, but the underlying cause for the anisotropy is unknown-both shape-preferred orientation of elastically heterogeneous materials and lattice-preferred orientation of a homogeneous material have been proposed. Both of these mechanisms imply that large-strain deformation occurs within the anisotropic regions, but the geodynamic implications of the mechanisms differ. Shape-preferred orientation would imply the presence of large elastic (and hence chemical) heterogeneity whereas lattice-preferred orientation requires deformation at high stresses. Here we show, on the basis of numerical modelling incorporating mineral physics of elasticity and development of lattice-preferred orientation, that slab deformation in the deep lower mantle can account for the presence of strong anisotropy in the circum-Pacific region. In this model-where development of the mineral fabric (the alignment of mineral grains) is caused solely by solid-state deformation of chemically homogeneous mantle material-anisotropy is caused by large-strain deformation at high stresses, due to the collision of subducted slabs with the core-mantle boundary. 相似文献