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The immature cerebral cortex self-organizes into local neuronal clusters long before it is activated by patterned sensory inputs. In the cortical anlage of newborn mammals, neurons coassemble through electrical or chemical synapses either spontaneously or by activation of transmitter-gated receptors. The neuronal network and the cellular mechanisms underlying this cortical self-organization process during early development are not completely understood. Here we show in an intact in vitro preparation of the immature mouse cerebral cortex that neurons are functionally coupled in local clusters by means of propagating network oscillations in the beta frequency range. In the newborn mouse, this activity requires an intact subplate and is strongly synchronized within a cortical column by gap junctions. With the developmental disappearance of the subplate at the end of the first postnatal week, activation of NMDA (N-methyl-D-aspartate) receptors in the immature cortical network is essential to generate this columnar activity pattern. Our findings show that during a brief developmental period the cortical network switches from a subplate-driven, gap-junction-coupled syncytium to a synaptic network acting through NMDA receptors to generate synchronized oscillatory activity, which may function as an early functional template for the development of the cortical columnar architecture. 相似文献
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The solar wind blows an immense magnetic bubble, the heliosphere, in the local interstellar medium (mostly neutral gas) flowing by the Sun. Recent measurements by Voyager 2 across the termination shock, where the solar wind is slowed to subsonic speeds before entering the heliosheath, found that the shocked solar wind plasma contains only approximately 20 per cent of the energy released by the termination shock, whereas energetic particles above approximately 28 keV contain only approximately 10 per cent; approximately 70 per cent of the energy is unaccounted for, leading to speculation that the unmeasured pickup ions or energetic particles below 28 keV contain the missing energy. Here we report the detection and mapping of heliosheath energetic ( approximately 4-20 keV) neutral atoms produced by charge exchange of suprathermal ions with interstellar neutral atoms. The energetic neutral atoms come from a source approximately 60 degrees wide in longitude straddling the direction of the local interstellar medium. Their energy spectra resemble those of solar wind pickup ions, but with a knee at approximately 11 keV instead of approximately 4 keV, indicating that their parent ions are pickup ions energized by the termination shock. These termination-shock-energized pickup ions contain the missing approximately 70 per cent of the energy dissipated in the termination shock, and they dominate the pressure in the heliosheath. 相似文献
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The loss of ions from Venus through the plasma wake 总被引:1,自引:0,他引:1
Barabash S Fedorov A Sauvaud JJ Lundin R Russell CT Futaana Y Zhang TL Andersson H Brinkfeldt K Grigoriev A Holmström M Yamauchi M Asamura K Baumjohann W Lammer H Coates AJ Kataria DO Linder DR Curtis CC Hsieh KC Sandel BR Grande M Gunell H Koskinen HE Kallio E Riihelä P Säles T Schmidt W Kozyra J Krupp N Fränz M Woch J Luhmann J McKenna-Lawlor S Mazelle C Thocaven JJ Orsini S Cerulli-Irelli R Mura M Milillo M Maggi M Roelof E Brandt P Szego K Winningham JD Frahm RA Scherrer J Sharber JR Wurz P 《Nature》2007,450(7170):650-653
Venus, unlike Earth, is an extremely dry planet although both began with similar masses, distances from the Sun, and presumably water inventories. The high deuterium-to-hydrogen ratio in the venusian atmosphere relative to Earth's also indicates that the atmosphere has undergone significantly different evolution over the age of the Solar System. Present-day thermal escape is low for all atmospheric species. However, hydrogen can escape by means of collisions with hot atoms from ionospheric photochemistry, and although the bulk of O and O2 are gravitationally bound, heavy ions have been observed to escape through interaction with the solar wind. Nevertheless, their relative rates of escape, spatial distribution, and composition could not be determined from these previous measurements. Here we report Venus Express measurements showing that the dominant escaping ions are O+, He+ and H+. The escaping ions leave Venus through the plasma sheet (a central portion of the plasma wake) and in a boundary layer of the induced magnetosphere. The escape rate ratios are Q(H+)/Q(O+) = 1.9; Q(He+)/Q(O+) = 0.07. The first of these implies that the escape of H+ and O+, together with the estimated escape of neutral hydrogen and oxygen, currently takes place near the stoichometric ratio corresponding to water. 相似文献
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Niklas Luhmann 《Systemic Practice and Action Research》1993,6(5):527-539
There is growing concern with how science and modern society can cope with major problems, especially those of an ecological kind. This has grown in parallel with a skepticism which questions our processes of rational decision making, questions our ability to plan, and questions our cognitive capacity for prediction and directing action. Faced with these problems, the scientific establishment demands more investment to increase levels of knowledge. It maintains that we can change and master the environment. But the way forward is to recognize the increasing uncertainties we face. Some theoretical development is possible in this area owing to the study of risk, but this needs generalizing to the level of society. An attempt is made in the final section to assimilate this particular theoretical approach with ideas in evolutionary theory. 相似文献
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Pearson RA Barber AC Rizzi M Hippert C Xue T West EL Duran Y Smith AJ Chuang JZ Azam SA Luhmann UF Benucci A Sung CH Bainbridge JW Carandini M Yau KW Sowden JC Ali RR 《Nature》2012,485(7396):99-103
Cell transplantation is a potential strategy for treating blindness caused by the loss of photoreceptors. Although transplanted rod-precursor cells are able to migrate into the adult retina and differentiate to acquire the specialized morphological features of mature photoreceptor cells, the fundamental question remains whether transplantation of photoreceptor cells can actually improve vision. Here we provide evidence of functional rod-mediated vision after photoreceptor transplantation in adult Gnat1?/? mice, which lack rod function and are a model of congenital stationary night blindness. We show that transplanted rod precursors form classic triad synaptic connections with second-order bipolar and horizontal cells in the recipient retina. The newly integrated photoreceptor cells are light-responsive with dim-flash kinetics similar to adult wild-type photoreceptors. By using intrinsic imaging under scotopic conditions we demonstrate that visual signals generated by transplanted rods are projected to higher visual areas, including V1. Moreover, these cells are capable of driving optokinetic head tracking and visually guided behaviour in the Gnat1?/? mouse under scotopic conditions. Together, these results demonstrate the feasibility of photoreceptor transplantation as a therapeutic strategy for restoring vision after retinal degeneration. 相似文献
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