关于长寿命mRNA的研究 Ⅳ.在植物贮藏器官——大蒜鳞茎中发现存在长寿命mRNA

本文报导在植物贮藏器官一大蒜鳞茎中首次发现长寿命mRNA。该长寿命mRNA贮存有鳞茎萌发和幼苗早期生长所需的信息,能够转译过氧化物酶和细胞色素氧化酶同工酶。     

Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer

Epimutations in the germline, such as methylation of the MLH1 gene, may contribute to hereditary cancer syndrome in human, but their transmission to offspring has never been documented. Here we report a family with inheritance, in three successive generations, of germline allele-specific and mosaic hypermethylation of the MSH2 gene, without evidence of DNA mismatch repair gene mutation. Three siblings carrying the germline methylation developed early-onset colorectal or endometrial cancers, all with microsatellite instability and MSH2 protein loss. Clonal bisulfite sequencing and pyrosequencing showed different methylation levels in different somatic tissues, with the highest level recorded in rectal mucosa and colon cancer tissue, and the lowest in blood leukocytes. This mosaic state of germline methylation with different tissue distribution could act as the first hit and provide a mechanism for genetic disease inheritance that may deviate from the mendelian pattern and be overlooked in conventional leukocyte-based genetic diagnosis strategy.     

低捻转杯纺纱实验与理论分析--提高低捻转杯纱强力探索

研究在转杯纺加捻区中加装阻扭件,然后选用相同的棉条纺制不同捻系数的转杯纱(加装阻扭件和不加装阻扭件)和环锭纱,并测试其成纱的强伸性能、表面形态和扭转性能.测试结果表明,加装阻扭件的转杯纱可以适当改善转杯纺的加捻效果,进而适当提高了转杯纱的成纱强力.     

Observations of passenger flow and verification of a crowd dynamics model

This paper reports observations of passenger flow in the Wuchang railway station in Wuhan, China during the Chinese Traditional Spring Festival in 2006. The data collected are used to verify a crowd dynamics model previously developed. The crowd dynamics model is based on simulating the global movement of each individual under the influence of the surrounding crowd, and the good agreement between the predictions and observations validates the prediction model. The crowd dynamics model suggests that the crowd movement speed is dominated by two factors： the front-back inter-person effect, and the pedestrian＇s self-motive. The first effect gives logarithmic relationship between the crowd speed and crowd density. The second factor depends on the individual motive driven with which people try to divorce themselves from the control of the crowd movement. The prediction model are helpful to guide the design of public traffic systems for effective crowd dispersal.     

预报林木生长的Kalman滤波器

<正>根据林木生长的随机性和动态性,用CAR模型自动辩识机辩知林木生长“多对多”动态系统的阶、参数。然后把得到的差分方程组变换成状态矩阵方程,在此基础上对林木生长动态进行Kalman滤波和实时预报,并给出了预报精度。     

最小二乘配点法解壳体弯曲问题

本文用最小二乘配点法分析弹性壳体弯曲问题。采用了加权残数法中的混合法—事先既不满足壳体弯曲定解微分方程式亦不满足边界条件,所选试函数为文献[1]中提到的双重幂级数。对于4边简支圆柱壳,其数值计算解与经典解析解误差不超过1.5％;对于悬臂圆柱壳,取其特例一悬臂效分析时,其结果与解析解误差亦不大。用本法可以编制出壳体弯曲问题的通用计算程序。