排序方式: 共有4条查询结果,搜索用时 140 毫秒
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人类乙型肝炎病毒的核衣壳由核心蛋白的二聚体所组成.但是,核心蛋白亚单位与亚单位之间相互作用的机制至今尚不清楚.研究发现,在人类乙型肝炎样病毒──土拨鼠肝炎病毒(WHV)核心蛋白的氨基端,存在着4个保守的疏水氨基酸残基(氨基酸位置101~102).它们分别是亮氨酸101,亮氨酸108,缬氨酸115和苯丙氨酸122.这4个疏水氨基酸残基以每隔6个氨基酸残基而重复出现1次.它们被称为“第7位疏水性氨基酸重复肽段(hhr)”.由于蛋白质中的疏水键往往在蛋白质的相互作用中起重要作用,因此就在培养细胞系统中研究WHV核心蛋白的hhr区域在… 相似文献
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Zhou Z Zhu G Hariri AR Enoch MA Scott D Sinha R Virkkunen M Mash DC Lipsky RH Hu XZ Hodgkinson CA Xu K Buzas B Yuan Q Shen PH Ferrell RE Manuck SB Brown SM Hauger RL Stohler CS Zubieta JK Goldman D 《Nature》2008,452(7190):997-1001
Understanding inter-individual differences in stress response requires the explanation of genetic influences at multiple phenotypic levels, including complex behaviours and the metabolic responses of brain regions to emotional stimuli. Neuropeptide Y (NPY) is anxiolytic and its release is induced by stress. NPY is abundantly expressed in regions of the limbic system that are implicated in arousal and in the assignment of emotional valences to stimuli and memories. Here we show that haplotype-driven NPY expression predicts brain responses to emotional and stress challenges and also inversely correlates with trait anxiety. NPY haplotypes predicted levels of NPY messenger RNA in post-mortem brain and lymphoblasts, and levels of plasma NPY. Lower haplotype-driven NPY expression predicted higher emotion-induced activation of the amygdala, as well as diminished resiliency as assessed by pain/stress-induced activations of endogenous opioid neurotransmission in various brain regions. A single nucleotide polymorphism (SNP rs16147) located in the promoter region alters NPY expression in vitro and seems to account for more than half of the variation in expression in vivo. These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases. 相似文献
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俞民澍 《复旦学报(自然科学版)》1998,37(4):581-582
土拨鼠肝炎病毒(WHV)是一种哺乳类动物的肝炎病毒.这种病毒在结构和抗原怕与人类乙型肝炎病毒(HBV)非常相似.以往的研究报告指出,在一种称为鸭乙型肝炎病毒(DHBV)的Pre-S包膜蛋白中,含有一个特定区域.这一区域由天冬氨酸-天冬氨酸-脯氨酸-亮氨酸-亮氨酸(DDPLL)5个氨基酸残基所组成.已发现,这一区域在像DHBV这一类禽类乙肝病毒的病毒装配和分泌时所必需的(LenhoffR,SummersJ.JVirol,1994,68:4565~4571).在WHV的Pre-S包胰蛋白中第201个氨基酸到第205个氨基酸所包含的顺序,甘氨酸-天冬氨酸-脯氨… 相似文献
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