Chromosomes of three Asian mammals:Meriones meridianus (Rodentia: Gerbillinae),Spermophilopsis leptodactylus (Rodentia: Sciuridae),Ochotona rufescens (Lagomorpha: Ochotonidae)

Zusammenfassung Chromosomenanalyse von 3 asiatischen Säugetieren:Meriones meridianus (2n=50),Ochotona rufescens (2n=60) undSpermiophilopsis lepto-dactylus (2n=38), Deren 2n's und Karyotypen wurden mit verwandten Formen ninsichtlich der Geschlechter und Gattungen verglichen und zur Klassifizierung diskutiert.     

Phosphoglycerate kinase acts in tumour angiogenesis as a disulphide reductase

Disulphide bonds in secreted proteins are considered to be inert because of the oxidizing nature of the extracellular milieu. An exception to this rule is a reductase secreted by tumour cells that reduces disulphide bonds in the serine proteinase plasmin. Reduction of plasmin initiates proteolytic cleavage in the kringle 5 domain and release of the tumour blood vessel inhibitor angiostatin. New blood vessel formation or angiogenesis is critical for tumour expansion and metastasis. Here we show that the plasmin reductase isolated from conditioned medium of fibrosarcoma cells is the glycolytic enzyme phosphoglycerate kinase. Recombinant phosphoglycerate kinase had the same specific activity as the fibrosarcoma-derived protein. Plasma of mice bearing fibrosarcoma tumours contained several-fold more phosphoglycerate kinase, as compared with mice without tumours. Administration of phosphoglycerate kinase to tumour-bearing mice caused an increase in plasma levels of angiostatin, and a decrease in tumour vascularity and rate of tumour growth. Our findings indicate that phosphoglycerate kinase not only functions in glycolysis but is secreted by tumour cells and participates in the angiogenic process as a disulphide reductase.     

Chromosomes of the Asian chipmunkEutamias Sibiricus laxmann (rodentia: Sciuridae)

Zusammenfassung Der Karyotyp vonEutamius sibiricus Laxmann (2n=38) ist ein neuer Typus, der von den früher beschriebenen Karyotypen vonEutamias- undTamias-Arten abweicht. Der Karyotyp vonE. sibiricus weicht von den Karyotypen anderer Tamiini durch das Vorkommen von 4 «Rearrangements» ab, während die Karyotypen der Tamiini aus Nordamerika nur in einem «Rearrangement» voneinander differieren.     

A great earthquake doublet and seismic stress transfer cycle in the central Kuril islands

Temporal variations of the frictional resistance on subduction-zone plate boundary faults associated with the stick-slip cycle of large interplate earthquakes are thought to modulate the stress regime and earthquake activity within the subducting oceanic plate. Here we report on two great earthquakes that occurred near the Kuril islands, which shed light on this process and demonstrate the enhanced seismic hazard accompanying triggered faulting. On 15 November 2006, an event of moment magnitude 8.3 ruptured the shallow-dipping plate boundary along which the Pacific plate descends beneath the central Kuril arc. The thrust ruptured a seismic gap that previously had uncertain seismogenic potential, although the earlier occurrence of outer-rise compressional events had suggested the presence of frictional resistance. Within minutes of this large underthrusting event, intraplate extensional earthquakes commenced in the outer rise region seaward of the Kuril trench, and on 13 January 2007, an event of moment magnitude 8.1 ruptured a normal fault extending through the upper portion of the Pacific plate, producing one of the largest recorded shallow extensional earthquakes. This energetic earthquake sequence demonstrates the stress transfer process within the subducting lithosphere, and the distinct rupture characteristics of these great earthquakes illuminate differences in seismogenic properties and seismic hazard of such interplate and intraplate faults.     

Implication of gut microbiota metabolites in cardiovascular and metabolic diseases

Evidence from the literature keeps highlighting the impact of mutualistic bacterial communities of the gut microbiota on human health. The gut microbita is a complex ecosystem of symbiotic bacteria which contributes to mammalian host biology by processing, otherwise, indigestible nutrients, supplying essential metabolites, and contributing to modulate its immune system. Advances in sequencing technologies have enabled structural analysis of the human gut microbiota and allowed detection of changes in gut bacterial composition in several common diseases, including cardiometabolic disorders. Biological signals sent by the gut microbiota to the host, including microbial metabolites and pro-inflammatory molecules, mediate microbiome–host genome cross-talk. This rapidly expanding line of research can identify disease-causing and disease-predictive microbial metabolite biomarkers, which can be translated into novel biodiagnostic tests, dietary supplements, and nutritional interventions for personalized therapeutic developments in common diseases. Here, we review results from the most significant studies dealing with the association of products from the gut microbial metabolism with cardiometabolic disorders. We underline the importance of these postbiotic biomarkers in the diagnosis and treatment of human disorders.     

Seismic detection of folded, subducted lithosphere at the core-mantle boundary

Seismic tomography has been used to infer that some descending slabs of oceanic lithosphere plunge deep into the Earth's lower mantle. The fate of these slabs has remained unresolved, but it has been postulated that their ultimate destination is the lowermost few hundred kilometres of the mantle, known as the D' region. Relatively cold slab material may account for high seismic velocities imaged in D' beneath areas of long-lived plate subduction, and for reflections from a seismic velocity discontinuity just above the anomalously high wave speed regions. The D' discontinuity itself is probably the result of a phase change in relatively low-temperature magnesium silicate perovskite. Here, we present images of the D' region beneath the Cocos plate using Kirchhoff migration of horizontally polarized shear waves, and find a 100-km vertical step occurring over less than 100 km laterally in an otherwise flat D' shear velocity discontinuity. Folding and piling of a cold slab that has reached the core-mantle boundary, as observed in numerical and experimental models, can account for the step by a 100-km elevation of the post-perovskite phase boundary due to a 700 degrees C lateral temperature reduction in the folded slab. We detect localized low velocities at the edge of the slab material, which may result from upwellings caused by the slab laterally displacing a thin hot thermal boundary layer.