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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer 总被引:26,自引:0,他引:26
Tomlinson IP Alam NA Rowan AJ Barclay E Jaeger EE Kelsell D Leigh I Gorman P Lamlum H Rahman S Roylance RR Olpin S Bevan S Barker K Hearle N Houlston RS Kiuru M Lehtonen R Karhu A Vilkki S Laiho P Eklund C Vierimaa O Aittomäki K Hietala M Sistonen P Paetau A Salovaara R Herva R Launonen V Aaltonen LA;Multiple Leiomyoma Consortium 《Nature genetics》2002,30(4):406-410
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P. Toivanen Helinä Siikala P. Laiho T. Paavilainen 《Cellular and molecular life sciences : CMLS》1967,23(7):560-561
Zusammenfassung Die Adjuvans-Arthritis konnte durch Östrontherapie gehemmt werden auf gleiche Weise bei intakten Ratten wie bei Ratten nach bilateraler Adrenalektomie, Ovariektomie oder nach Adrenal- und Ovariektomie. Bei hypophysektomierten Tieren (ohne Östrontherapie) war das Krankheitsbild bedeutend milder als bei intaken Kontrollratten. 相似文献
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Tschumperlin DJ Dai G Maly IV Kikuchi T Laiho LH McVittie AK Haley KJ Lilly CM So PT Lauffenburger DA Kamm RD Drazen JM 《Nature》2004,429(6987):83-86
Physical forces elicit biochemical signalling in a diverse array of cells, tissues and organisms, helping to govern fundamental biological processes. Several hypotheses have been advanced that link physical forces to intracellular signalling pathways, but in many cases the molecular mechanisms of mechanotransduction remain elusive. Here we find that compressive stress shrinks the lateral intercellular space surrounding epithelial cells, and triggers cellular signalling via autocrine binding of epidermal growth factor family ligands to the epidermal growth factor receptor. Mathematical analysis predicts that constant rate shedding of autocrine ligands into a collapsing lateral intercellular space leads to increased local ligand concentrations that are sufficient to account for the observed receptor signalling; direct experimental comparison of signalling stimulated by compressive stress versus exogenous soluble ligand supports this prediction. These findings establish a mechanism by which mechanotransduction arises from an autocrine ligand-receptor circuit operating in a dynamically regulated extracellular volume, not requiring induction of force-dependent biochemical processes within the cell or cell membrane. 相似文献
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