Physiology: does gut hormone PYY3-36 decrease food intake in rodents?

Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.     

LaConf:A Localized Address Autoconfiguration Scheme for Wireless Ad Hoc Networks

We propose a localized address autoconfiguration (LaConf) scheme for wireless ad hoc networks.Address allocation information is maintained on the network border nodes,called addressing agents (AAs),which are locally identified by a geographic routing protocol GFG (Greedy-FACE-Greedy).When a node joins the network,it acquires an address from a neighboring AA (if any exists) by local communication or from the head AA (a geographic extreme AA) by GFG-based multi-hop communication.A Geographic Hash Table (GHT) ...     

A new polarographic procedure for measuring the blood oxygen tensionin vitro

Zusammenfassung Es wird ein neues und einfaches polarographisches Verfahren unter Benützung von Clarks Platinelektrode beschrieben, das die Messung der Sauerstoffspannung des Blutesin vitro gestattet.     

The importance of repairing stalled replication forks

The bacterial SOS response to unusual levels of DNA damage has been recognized and studied for several decades. Pathways for re-establishing inactivated replication forks under normal growth conditions have received far less attention. In bacteria growing aerobically in the absence of SOS-inducing conditions, many replication forks encounter DNA damage, leading to inactivation. The pathways for fork reactivation involve the homologous recombination systems, are nonmutagenic, and integrate almost every aspect of DNA metabolism. On a frequency-of-use basis, these pathways represent the main function of bacterial DNA recombination systems, as well as the main function of a number of other enzymatic systems that are associated with replication and site-specific recombination.     

计算交换代数2

计算交换代数将要成为这个世纪应用到现实世界的最为重要的数学工具之一，随着当今计算技术的飞速发展，采用符号计算的方法处理工业尺度的问题已经成为现实。本书的主要目的是继续为这种发展趋势提供理论基础，深入其中将可以发现与现世界相关的很多线索和暗示。虽然数值方法至今依然占据着统治地位，符号方法被视作数值方法的补充；虽然少数计算机代数系统（包括CoCoA）提供了进行混合计算的可能（例如混合了数值和符号方法），