论信息市场环境下的图书馆营销观

分析了信息市场的发展对图书馆信息资源建设、信息技术的开发以及信息传播方式和获取手段所产生的影响，探讨了面对激烈的市场竞争图书馆引入营销观念的必要性，并对具体的营销策略做了详尽的阐述。     

Evidence for a spin-aligned neutron-proton paired phase from the level structure of (92)Pd

Shell structure and magic numbers in atomic nuclei were generally explained by pioneering work that introduced a strong spin-orbit interaction to the nuclear shell model potential. However, knowledge of nuclear forces and the mechanisms governing the structure of nuclei, in particular far from stability, is still incomplete. In nuclei with equal neutron and proton numbers (N = Z), enhanced correlations arise between neutrons and protons (two distinct types of fermions) that occupy orbitals with the same quantum numbers. Such correlations have been predicted to favour an unusual type of nuclear superfluidity, termed isoscalar neutron-proton pairing, in addition to normal isovector pairing. Despite many experimental efforts, these predictions have not been confirmed. Here we report the experimental observation of excited states in the N = Z = 46 nucleus (92)Pd. Gamma rays emitted following the (58)Ni((36)Ar,2n)(92)Pd fusion-evaporation reaction were identified using a combination of state-of-the-art high-resolution γ-ray, charged-particle and neutron detector systems. Our results reveal evidence for a spin-aligned, isoscalar neutron-proton coupling scheme, different from the previous prediction. We suggest that this coupling scheme replaces normal superfluidity (characterized by seniority coupling) in the ground and low-lying excited states of the heaviest N = Z nuclei. Such strong, isoscalar neutron-proton correlations would have a considerable impact on the nuclear level structure and possibly influence the dynamics of rapid proton capture in stellar nucleosynthesis.     

水稻枝梗数性状的遗传研究进展

水稻穗部枝梗教影响稻谷产量.就穗部一、二次枝梗数性状的遗传研究进行了综述.研究表明枝梗数是受多基因控制的数量性状,具高的遗传力和变异度,其基因的表达受水分胁迫、不同年份的影响,并存在基因间上位性以及基因型与环境间互作;枝梗数与稻谷产量呈正相关:在早期世代和高代分别对一次枝梗数和二次枝梗数进行选择有较好效果.     

L(p)(p>1)‖f‖_p与E_f(p)中的连续性

证明 了 Ｌ （ｐ）（ｐ＞ １）中‖ ｆ‖ 与 Ｅ （ｐ）关 于 ｐ 的 连续 性 ，即 ：当 ｐ０＞ ｐ＞１，ｆ（ｘ）∈ ｐ ｆＬＰ （Ｅ ）时 ，ｌｉｍ ‖ ｆ‖_ｐ ＝‖ ｆ‖_Ｐ ，ｌｉｍ Ｅ （ｐ）＝Ｅ （ｐ０）。 ０ ０ ｆ ｆ ｐ→ｐ０ ｐ→ｐ０     

A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export

Superfamily 1 and superfamily 2 RNA helicases are ubiquitous messenger-RNA-protein complex (mRNP) remodelling enzymes that have critical roles in all aspects of RNA metabolism. The superfamily 2 DEAD-box ATPase Dbp5 (human DDX19) functions in mRNA export and is thought to remodel mRNPs at the nuclear pore complex (NPC). Dbp5 is localized to the NPC via an interaction with Nup159 (NUP214 in vertebrates) and is locally activated there by Gle1 together with the small-molecule inositol hexakisphosphate (InsP(6)). Local activation of Dbp5 at the NPC by Gle1 is essential for mRNA export in vivo; however, the mechanistic role of Dbp5 in mRNP export is poorly understood and it is not known how Gle1(InsP6) and Nup159 regulate the activity of Dbp5. Here we report, from yeast, structures of Dbp5 in complex with Gle1(InsP6), Nup159/Gle1(InsP6) and RNA. These structures reveal that InsP(6) functions as a small-molecule tether for the Gle1-Dbp5 interaction. Surprisingly, the Gle1(InsP6)-Dbp5 complex is structurally similar to another DEAD-box ATPase complex essential for translation initiation, eIF4G-eIF4A, and we demonstrate that Gle1(InsP6) and eIF4G both activate their DEAD-box partner by stimulating RNA release. Furthermore, Gle1(InsP6) relieves Dbp5 autoregulation and cooperates with Nup159 in stabilizing an open Dbp5 intermediate that precludes RNA binding. These findings explain how Gle1(InsP6), Nup159 and Dbp5 collaborate in mRNA export and provide a general mechanism for DEAD-box ATPase regulation by Gle1/eIF4G-like activators.     

采用图像信息学方法研究三维支架中细胞的信号通路

通过慢病毒介导的短发夹RNA对成纤维细胞的转化生长因子β(TGF-β)信号通路进行干扰,采用双光子荧光显微成像技术并结合基于细胞-细胞外基质三维系统的图像信息学方法,研究了植于多孔胶原蛋白支架中成纤维细胞分化过程的TGF-β信号通路.结果表明,在介导成纤维细胞分化的过程中,生长因子TGF-β1比TGF-β3发挥的作用更大,在TGF-β1介导的成纤维细胞分化过程中,蛋白SMAD1和SMAD3通过不同方式也发挥了重要作用.所得结果与通过生化或遗传学方法的结果相吻合.     

Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys

A recombinant adenovirus serotype 5 (rAd5) vector-based vaccine for HIV-1 has recently failed in a phase 2b efficacy study in humans. Consistent with these results, preclinical studies have demonstrated that rAd5 vectors expressing simian immunodeficiency virus (SIV) Gag failed to reduce peak or setpoint viral loads after SIV challenge of rhesus monkeys (Macaca mulatta) that lacked the protective MHC class I allele Mamu-A*01 (ref. 3). Here we show that an improved T-cell-based vaccine regimen using two serologically distinct adenovirus vectors afforded substantially improved protective efficacy in this challenge model. In particular, a heterologous rAd26 prime/rAd5 boost vaccine regimen expressing SIV Gag elicited cellular immune responses with augmented magnitude, breadth and polyfunctionality as compared with the homologous rAd5 regimen. After SIV(MAC251) challenge, monkeys vaccinated with the rAd26/rAd5 regimen showed a 1.4 log reduction of peak and a 2.4 log reduction of setpoint viral loads as well as decreased AIDS-related mortality as compared with control animals. These data demonstrate that durable partial immune control of a pathogenic SIV challenge for more than 500 days can be achieved by a T-cell-based vaccine in Mamu-A*01-negative rhesus monkeys in the absence of a homologous Env antigen. These findings have important implications for the development of next-generation T-cell-based vaccine candidates for HIV-1.     

输液瓶的吸附作用对胰岛素输注过程中浓度变化的影响

为了解胰岛素注射液在输液过程中的浓度变化情况,指导临床合理操作,模拟了临床胰岛素配液以及输注操作过程,实验分为玻璃瓶组和塑料瓶组,各组又按操作的不同分为输液组和吸附组.采用紫外分光光度法测定胰岛素浓度.输液组流速为50滴/min,每输注50 mL液体取样测定胰岛素浓度.吸附组按溶媒不同分为氯化钠组、50 g/L葡萄糖组和100 g/L葡萄糖组,每隔10 min轻轻振摇1次,并取液测定浓度.结果表明,不同材质和装有不同溶媒的输液瓶对胰岛素的吸附趋势类似,但塑料瓶对胰岛素的吸附量大于玻璃瓶,装有氯化钠的输液瓶大于葡萄糖输液瓶,100 g/L葡萄糖输液瓶大于50 g/L葡萄糖输液瓶.因此,在胰岛素输液过程中,应考虑到输液瓶对胰岛素的吸附导致的药量损失.     

直线永磁振动电机的磁场与静推力特性分析

主要介绍了一种直线永磁振动电机的结构及其工作原理，并用有限元软件对其在不同位置时的磁场进行了分析，同时搭建实验台做了实际的测试，给出了误差及出现误差的原因。该电机结构简单，可靠性高，寿命长，易维护，并且控制电路简单，运行平稳，适用于小功率电磁间的开关系统中。