Observation of conformation-specific pathways in the photodissociation of 1-iodopropane ions.

Many molecules can rotate freely around single bonds and thereby interconvert between different conformations, such as gauche and anti 1,2-disubstituted ethane, a classic example of conformational isomerism. Even though rotation occurs rapidly at room temperature, the product selectivity seen in some reactions has been explained by conformation-dependent reaction mechanisms: if reactant molecules differing only in their conformation are located at different positions on the reaction path, they may undergo different reactions. But a direct verification of this effect is difficult, because the energy barrier separating conformational isomers is so low that under ambient conditions reactants with more than one conformation will be present. But by using temperatures low enough to suppress the interconversion between different conformations, gauche-1-iodopropane ions and anti-1-iodopropane ions have been selectively generated. Here we show that the kinetic energy released during the photodissociation of 1-iodopropane ions depends strongly on the conformation of the ions. Thermodynamic arguments and ab initio calculations indicate that this difference in kinetic energy release results from differences in the reaction mechanism, with gauche-1-iodopropane ions forming 2-propyl ions and anti-1-iodopropane ions forming protonated cyclopropane ions. These findings suggest that the well-known concept of conformation selection forms the basis of a simple scheme for reaction control, thus providing in some cases an attractive alternative for more involved schemes that utilize the phase and pulse shape of laser beams to control chemical reactions.     

跳跃点统计检测的小波方法及其在金融汇率中的应用

跳跃点统计检测的小波方法及其在金融汇率中的应用１）黄香叶维彰（香港理工大学应用数学系，香港，九龙）栾贻会谢衷洁（北京大学数学学院概率统计系，北京，１００８７１）关键词小波；跃点检测；汇率中图分类号Ｏ２１１；Ｏ２１２０引言近年来，小波分析已引入到统计领...     

S-PPM:韩国质量革新计划

从1995年开始实行的韩国质量革新计划(SinglePPM)运动是为了提高从合作企业纳入的产品质量。此项运动的目标是将包括成品不合格率和区域索赔的交货不合格率减少至10ppm以内或100ppm以下。至今,从韩国政府获得S-PPM认证的企业有1053家。这项质量革新计划不单纯是为提高产品质量,而且也为提高企业的信誉度做贡献。     

燃气流量低频脉动下的火焰结构特征

针对一种可降低天然气高温燃烧过程中NOx生成量的脉动供燃料燃烧技术,研究了一个采用燃气流量脉动燃烧方式的射流扩散火焰。采用纹影和直接摄像手段观察了在燃气流量低频率(10Hz以下)脉动工况下的火焰特征及其变化,分析了火焰长度脉动特征和火焰内部结构的周期发展过程。研究发现:火焰内部结构的周期发展过程包括高速(波峰流量)燃气脉冲冲出、增长、燃气惯性冲出、回吸、低速(波谷流量)和高速燃气脉冲的分离、低速脉冲的增长等阶段。其中低速和高速燃气脉冲的分离是单火焰燃烧不稳定的原因。     

Interleukin-33 stimulates formation of functional osteoclasts from human CD14+ monocytes

Interleukin (IL)-33 is a recently described pro-inflammatory cytokine. Here we demonstrate IL-33 as a regulator of functional osteoclasts (OCs) from human CD14⁺ monocytes. IL-33 stimulates formation of tartrate-resistant acid phosphatase (TRAP)⁺ multinuclear OCs from monocytes. This action was suppressed by anti-ST2 antibody, suggesting that IL-33 acts through its receptor ST2, but not by the receptor activator of NF-κB ligand (RANKL) decoy, osteoprotegerin, or anti-RANKL antibody. IL-33 stimulated activating phosphorylations of signaling molecules in monocytes that are critical for OC development. These included Syk, phospholipase Cγ2, Gab2, MAP kinases, TAK-1, and NF-κB. IL-33 also enhanced expression of OC differentiation factors including TNF-α receptor-associated factor 6 (TRAF6), nuclear factor of activated T cells cytoplasmic 1, c-Fos, c-Src, cathepsin K, and calcitonin receptor. IL-33 eventually induced bone resorption. This study suggests that the osteoclastogenic property of IL-33 is mediated through TRAF6 as well as the immunoreceptor tyrosine-based activation motif-dependent Syk/PLCγ pathway in human CD14⁺ monocytes.     

Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

Human non-small cell lung cancers (NSCLCs) with activating mutations in EGFR frequently respond to treatment with EGFR-targeted tyrosine kinase inhibitors (TKIs), such as erlotinib, but responses are not durable, as tumors acquire resistance. Secondary mutations in EGFR (such as T790M) or upregulation of the MET kinase are found in over 50% of resistant tumors. Here, we report increased activation of AXL and evidence for epithelial-to-mesenchymal transition (EMT) in multiple in vitro and in vivo EGFR-mutant lung cancer models with acquired resistance to erlotinib in the absence of the EGFR p.Thr790Met alteration or MET activation. Genetic or pharmacological inhibition of AXL restored sensitivity to erlotinib in these tumor models. Increased expression of AXL and, in some cases, of its ligand GAS6 was found in EGFR-mutant lung cancers obtained from individuals with acquired resistance to TKIs. These data identify AXL as a promising therapeutic target whose inhibition could prevent or overcome acquired resistance to EGFR TKIs in individuals with EGFR-mutant lung cancer.     

气－固流动系统无干扰测量设备的新进展

为了在气－固流动系统过程中确定运输特性，证实理论预报和仪设计程序公式化，必须对气－固两相流的各相质量流量、密度和局部地区的流速进行测量，对于某种相（诸如一群固体颗粒）的密度进行直接测量时需要有一种基本测量标准，激光多普勤相测定仪在一定条件下可以测定局部地区的瞬时密度，因而可用作基本测量标准，其它光学方法及中子束方法由于需要用质量流量进行标定，因而只能用作间接的测量标准，本文对无干扰测试设备的新进展进行了综述，对激光多普勒测速仪（ＬＤＶ）、相多普勤颗粒分析仪（ＰＤＰＡ）直至核磁共振测速仪的性能、限制因素及应用前景作了概述和讨论。     

Development operators on 4D moving object databases

In this paper we propose four-dimensional (4D) operators,which can be used to deal with sequential changes of topological relationships between 4D moving objects and we call them 4D development operators. In contrast to the existing operators,we can apply the operators to real applications on 4D moving objects. We also propose a new approach to define them. The approach is based on a dimension-separated method,which considers x-y coordinates and ( coordinates separately. In order to show the applicability of our operators,we show the algorithms for the proposed operators and development graph between 4D moving objects.     

Version based spatial record management techniques for spatial database management system

The search operation of spatial data was a principal operation in existent spatial database management system, but the update operation of spatial data such as tracking are occurring frequently in the spatial database management system recently. So, necessity of concurrency improvement among transactions is increasing. In general database management system, many techniques have been studied to solve concurrency problem of transaction. Among them, multi-version algorithm does to minimize interference among transactions. However, to apply existent multi-version algorithm to improve concurrency of transaction to spatial database management system, the waste of storage happens because it must store entire version for spatial record even if only aspatial data of spatial record is changed. This paper has proposed the record management techniques to manage separating aspatial data version and spatial data version to decrease waste of storage for record version and improve concurrency among transactions.