The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier.     

现代信息技术在大学英语教学中的应用

从信息技术的发展趋势入手,分析了信息技术在英语教学中的应用现状,提出了进一步加强信息技术与英语教学整合的措施。     

混合氯化稀土催化合成DOP,DOM和DOA

本文报道:价廉的混合氯化稀土,对合成DOP等增塑剂有明显的催化效果。产品精制简单,转化率高,有应用前景。     

Face Recognition Based on Support Vector Machine and Nearest Neighbor Classifier

Support vector machine (SVM), as a novel approach in pattern recognition, has demonstrated a success in face detection and face recognition. In this paper, a face recognition approach based on the SVM classifier with the nearest neighbor classifier (NNC) is proposed. The principal component analysis (PCA) is used to reduce the dimension and extract features. Then one-against-all stratedy is used to train the SVM classifiers. At the testing stage, we propose an al-     

基于PLC实现等离子弧喷涂电流调节

在等离子弧喷涂过程中,要求电流在喷涂开始时有递增和结束后有衰减的过程.在以可编程控制器为核心的喷涂主控系统里,通过模拟量输入输出模块EM235和CF2B-2A型可控硅触发器及辅助电路,利用PLC程序实现了喷涂电流的递增、衰减过程.     

Evolutionary Computation and its Application

On Mar.23,2006,a project in the Major Program of NSFC-"Evolutionary computation and its application",managed by Prof.Licheng Jiao,Prof.Lishan Kang,Prof.Zhenya He,and Prof.Tao Xie,passed its Final Qualification Process and was evaluated as Excellent.     

高铁混合垢化学清洗技术

作者研制了高铁混合垢的化学清洗配方及工艺,经生产应用收到了良好效果,除垢率及缓蚀率均超过劳动部标准和水利电力部标准.     

浅析地方公共图书馆存在的问题及对策

目前,一些地方公共图书馆落后的组织结构、管理方式以及淡薄的服务意识,已远远不能适应当前社会的需要。针对地方公共图书馆存在的问题,提出一系列改进措施,旨在使地方图书馆更好地为社会公众服务。     

步进电机细分技术在经济型数控机床中的应用

本文叙述了步进电机细分原理及微机控制系统，并将其应用于经济型数控铣床的横向进给伺服系统，有效提高了开环数控系统的定位精度。     

An Improved S-Random Interleaver Design for Turbo Code Based on Chaos Model

A new method to design interleaver based on Henon chaos model is presented. The designed interleaver is with rather random behavior. Experimental results show that the proposed S-henon interleaver make a magnitude of im provement in bit error rate （BER） performance by 0.4 dB compared with the S-random interleaver for AWGN channel respectively. The S-henon interleaver may be adapted to 3G mobile communication systems.