排序方式: 共有5条查询结果,搜索用时 0 毫秒
1
1.
Burdon KP Macgregor S Hewitt AW Sharma S Chidlow G Mills RA Danoy P Casson R Viswanathan AC Liu JZ Landers J Henders AK Wood J Souzeau E Crawford A Leo P Wang JJ Rochtchina E Nyholt DR Martin NG Montgomery GW Mitchell P Brown MA Mackey DA Craig JE 《Nature genetics》2011,43(6):574-578
We report a genome-wide association study for open-angle glaucoma (OAG) blindness using a discovery cohort of 590 individuals with severe visual field loss (cases) and 3,956 controls. We identified associated loci at TMCO1 (rs4656461[G] odds ratio (OR) = 1.68, P = 6.1 × 10(-10)) and CDKN2B-AS1 (rs4977756[A] OR = 1.50, P = 4.7 × 10(-9)). We replicated these associations in an independent cohort of cases with advanced OAG (rs4656461 P = 0.010; rs4977756 P = 0.042) and two additional cohorts of less severe OAG (rs4656461 combined discovery and replication P = 6.00 × 10(-14), OR = 1.51, 95% CI 1.35-1.68; rs4977756 combined P = 1.35 × 10(-14), OR = 1.39, 95% CI 1.28-1.51). We show retinal expression of genes at both loci in human ocular tissues. We also show that CDKN2A and CDKN2B are upregulated in the retina of a rat model of glaucoma. 相似文献
2.
Summary A single topical application of precocene I or precocene II inhibits the normal process of vitellogenesis inDrosophila melanogaster. This effect is partly prevented by treatment with JH-11 or spontaneously reversible with time.This work was supported in part by NIH grants AI 15662 and GM 22711. 相似文献
3.
A total of 19 cestodes, Ophiotaenia sp., were recovered by deworming from adult Colorado River Squawfish ( Pteichocheilius licius ) maintained at the U.S. National Fish Hatchery at Willow Beach, Arizona. These specimens differ from other described species and are named Ophiotaenia critica. 相似文献
4.
5.
Weber T Czasch AO Jagutzki O Müller AK Mergel V Kheifets A Rotenberg E Meigs G Prior MH Daveau S Landers A Cocke CL Osipov T Díez Muiño R Schmidt-Böcking H Dörner R 《Nature》2004,431(7007):437-440
All properties of molecules--from binding and excitation energies to their geometry--are determined by the highly correlated initial-state wavefunction of the electrons and nuclei. Details of these correlations can be revealed by studying the break-up of these systems into their constituents. The fragmentation might be initiated by the absorption of a single photon, by collision with a charged particle or by exposure to a strong laser pulse: if the interaction causing the excitation is sufficiently understood, the fragmentation process can then be used as a tool to investigate the bound initial state. The interaction and resulting fragment motions therefore pose formidable challenges to quantum theory. Here we report the coincident measurement of the momenta of both nuclei and both electrons from the single-photon-induced fragmentation of the deuterium molecule. The results reveal that the correlated motion of the electrons is strongly dependent on the inter-nuclear separation in the molecular ground state at the instant of photon absorption. 相似文献
1