排序方式: 共有23条查询结果,搜索用时 0 毫秒
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More false-positive problems 总被引:9,自引:0,他引:9
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Relaxin and its structural relationship to insulin 总被引:2,自引:0,他引:2
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Steroid hormones in sickle-cell disease 总被引:1,自引:0,他引:1
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A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse 总被引:37,自引:0,他引:37
Nolan PM Peters J Strivens M Rogers D Hagan J Spurr N Gray IC Vizor L Brooker D Whitehill E Washbourne R Hough T Greenaway S Hewitt M Liu X McCormack S Pickford K Selley R Wells C Tymowska-Lalanne Z Roby P Glenister P Thornton C Thaung C Stevenson JA Arkell R Mburu P Hardisty R Kiernan A Erven A Steel KP Voegeling S Guenet JL Nickols C Sadri R Nasse M Isaacs A Davies K Browne M Fisher EM Martin J Rastan S Brown SD Hunter J 《Nature genetics》2000,25(4):440-443
As the human genome project approaches completion, the challenge for mammalian geneticists is to develop approaches for the systematic determination of mammalian gene function. Mouse mutagenesis will be a key element of studies of gene function. Phenotype-driven approaches using the chemical mutagen ethylnitrosourea (ENU) represent a potentially efficient route for the generation of large numbers of mutant mice that can be screened for novel phenotypes. The advantage of this approach is that, in assessing gene function, no a priori assumptions are made about the genes involved in any pathway. Phenotype-driven mutagenesis is thus an effective method for the identification of novel genes and pathways. We have undertaken a genome-wide, phenotype-driven screen for dominant mutations in the mouse. We generated and screened over 26,000 mice, and recovered some 500 new mouse mutants. Our work, along with the programme reported in the accompanying paper, has led to a substantial increase in the mouse mutant resource and represents a first step towards systematic studies of gene function in mammalian genetics. 相似文献
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Sun J Zheng SL Wiklund F Isaacs SD Purcell LD Gao Z Hsu FC Kim ST Liu W Zhu Y Stattin P Adami HO Wiley KE Dimitrov L Sun J Li T Turner AR Adams TS Adolfsson J Johansson JE Lowey J Trock BJ Partin AW Walsh PC Trent JM Duggan D Carpten J Chang BL Grönberg H Isaacs WB Xu J 《Nature genetics》2008,40(10):1153-1155
We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, approximately 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 x 10(-9) for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP. 相似文献
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Thelma Isaacs 《Cellular and molecular life sciences : CMLS》1969,25(3):239-240
Zusammenfassung Ca3Y2Ge3O12 wurde in chemisch homogener Form auf hydrothermalem Weg hergestellt. Es besitzt eine Garnet-Struktur mit dem Gitterparametera
0=12,804 Å. 相似文献
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