Effects of Carbon Content and Solidification Rate on the Thermal Conductivity of Grey Cast Iron

The thermal conductivity/diffusivity of pearlitic grey irons with various carbon contents was investigated by the laser flash method. The materials were cast in controlled thermal environments producing three dissimilar cooling rates. The cooling rates together with the carbon content largely influence the thermal conductivity of grey iron. Linear relationships exist between the thermal conductivity and the carbon content, the carbon equivalent, and the fraction of the former primary solidified austenite transformed into pearlite. The results show that the optimal thermal transport properties are obtained at medium cooling rates. Equations are given for the thermal conductivity of pearlite, solidified as pre-eutectic austenite, and the eutectic of grey iron. The thermal conductivity of pearlitic grey iron is modelled at both room temperature and elevated temperatures with good accuracy.     

Moisture Absorption, Mass Loss and Evaporative Resistance of Clothing in Transient Condition

The water vapour resistance of clothing ensembles is not as commonly determined as dry thermal insulation. The measurement techniques are more complicated and the measurement values differ among laboratories. Due to complicated moisture transfer process through clothing ensemble, the moisture absorbed and evaporated varies in transient and steady state phases depending on properties, thickness of clothing, and environmental conditions. The purpose of this study was to measure moisture gain inside hygroscopic underwear, and hydrophobic and permeable outer wear as a function of time, to investigate mass loss from ＂skin＂ as well as from the manikin, to quantify evaporative heat loss and total heat loss from the manikin, and to determine water vaponr resistance of clothing. Manikin Tore was used by wearing wet ＂skin＂ to simulate sweating condition. Moisture content in the inner garment gain shows an exponential relation against time. Moisture in the outer permeable layer shows little gain. On the contrary, mass loss directly from the wet skin decreases exponentially. The mass loss from the manikin is relatively stable throughout three test phases. The evaporative heat loss is about 2/3 of the total heat loss from the sweating manikin. While measuring the evaporative resistance of clothing ensembles with hygroscopic inner garment and permeable outer garment, unlike to measure ensembles with impermeable outer layer, one hour measurement time is enough to get relatively stable results. The variation between the 1^rt hour and the 3^nd hour is less than 5%. The length of transient period and measurement time is dependent on the permeability, thickness of clothing ensembles and environmental conditions.     

The blood flow of the cerebral cortex determined by radioactive krypton85

Zusammenfassung Der radioaktive indifferente Luftbestandteil Krypton⁸⁵ (in Ringer-Flüssigkeit) wird in die Arteria carotis communis injiziert und die Radioaktivität über der freigelegten Gehirnoberfläche verfolgt. Die Methode ergibt reproduzierbare quantitativecorticale Perfusionswerte und eignet sich auch für andere Gewebe.     

Measurement of tissuepCO2 in the brain

Zusammenfassung Der mittlerepCO₂ in der Gehirnrinde von Katzen wurde mittels einer neuen Elektrode kontinuierlich registriert. Es wird ein kurzer Bericht über die Messbedingungen, nebst Beispielen vonpCO₂-Veränderungen bei verschiedenen Funktionszuständen, gegeben.     

Inner nuclear membrane proteins: functions and targeting

We summarize the properties of integral membrane proteins that reside in the inner nuclear membrane, including lamin B receptor (LBR), lamina-associated polypeptide (LAP) 1, LAP2, emerin, MAN1 and nurim. Most of these proteins interact with lamins and chromatin. Some data also suggest more speculative functions such as gene regulation and possibly sterol metabolism. Mutations in emerin and nuclear lamins have been associated with muscular dystrophies and lipodystrophy, raising new questions about the functions of inner nuclear membrane proteins. Integral proteins of the inner nuclear membrane are synthesized on the rough endoplasmic reticulum (ER) and reach the inner nuclear membrane by lateral diffusion in the connected ER and nuclear envelope membranes. Associations with nuclear ligands retain them in the inner nuclear membrane. Further investigation of the functions and targeting of inner nuclear membrane proteins are needed to determine how they are involved in human disease.     

Genome-wide association study identifies three new melanoma susceptibility loci

We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additional 6,426 control subjects from French or British populations, all of whom were genotyped for 317,000 or 610,000 single-nucleotide polymorphisms (SNPs). Our analysis replicated previously known melanoma susceptibility loci. Seven new regions with at least one SNP with P < 10(-5) and further local imputed or genotyped support were selected for replication using two other genome-wide studies (from Australia and Texas, USA). Additional replication came from case-control series from the UK and The Netherlands. Variants at three of the seven loci replicated at P < 10(-3): an SNP in ATM (rs1801516, overall P = 3.4 × 10(-9)), an SNP in MX2 (rs45430, P = 2.9 × 10(-9)) and an SNP adjacent to CASP8 (rs13016963, P = 8.6 × 10(-10)). A fourth locus near CCND1 remains of potential interest, showing suggestive but inconclusive evidence of replication (rs1485993, overall P = 4.6 × 10(-7) under a fixed-effects model and P = 1.2 × 10(-3) under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series.     

A comprehensive linkage analysis for myocardial infarction and its related risk factors

Coronary artery disease and myocardial infarction (MI) are leading causes of death in the western world. Numerous studies have shown that risk factors such as diabetes mellitus, arterial hypertension and hypercholesterolemia contribute to the development of the disease. Although each risk factor by itself is partly under genetic control, a positive family history is an independent predictor, which suggests that there are additional susceptibility genes. We have scanned the whole genome in 513 families to identify chromosomal regions linked to myocardial infarction and related risk factors that are known to be under genetic control. Here we show, by using variance component analysis and incorporating risk factors, that risk of myocardial infarction maps to a single region on chromosome 14 with a significant lod score of 3.9 (pointwise P=0.00015, genome-wide P<0.05), providing evidence of a principal MI locus. To characterize this locus we analyzed each risk factor by itself. Serum concentrations of lipoprotein (a) show linkage to both the apolipoprotein (a) locus (lod score 26.99) and a new locus on chromosome 1 (lod score 3.8). There is suggestive linkage for diabetes mellitus on chromosome 6 (lod score 2.96), for hypertension on chromosomes 1 and 6, for high-density and low-density lipoprotein cholesterol on chromosomes 1 and 17, and for triglyceride concentrations on chromosome 9. Although some of these risk factors overlap with previously identified loci, none overlaps with the newly identified susceptibility locus for myocardial infarction and coronary artery disease.     

The effect of LSD-25 upon the cerebral blood flow and EEG in cats

Zusammenfassung Es wurde gezeigt, dass LSD-25 (d-Lysergsäure-diäthylamid) in Dosen von 30 bis 100 /kg Körpergewicht bei dernichtnarkotisierten Katze (encéphaleisolé) meistens cine Erhöhung des zerebralen Gefässwiderstandes herbeiführte. In die Carotis injiziert, gab LSD-25 in denselben Dosen nach vorübergehender, halbseitiger Aktivierung eine Depression des Elektroenzephalogrammes. Kleinere Dosen gaben im EEG eine Aktivierung oder waren ohne Wirkung.     

Effects of short chain fatty acid anions upon cortical blood flow and EEG in cats

Zusammenfassung Die Wirkung von intraven?s injizierten Fetts?ureanionen (0,5–1,0 molare L?sung in NaOH von Butters?ure und Kaprons?ure) auf das Elektroencephalogramm, auf den Blutdruck und auf die kortikale Durchblutung wurde bei leicht narkotisierten und nichtnarkotisierten Katzen untersucht. Es wurde best?tigt, dass Fetts?ureanionen eine ausgesprochene Depression des Elektroencephalogramms herbeiführen. Weitcrhin wurde gezeigt, dass sich mit dieser Depression auch eine bedeutende Herabsetzung des kortikalen Gef?sswiderstandes entwickelt.