排序方式: 共有12条查询结果,搜索用时 46 毫秒
1.
于焱 《中国人民公安大学学报(自然科学版)》2002,(5):45-48
随着计算机技术应用的普及和指纹识别技术的日益完善,现行的暂住人口身份证管理系统已逐步呈现出许多缺点和弊端.为解决近年来出现的诸多问题,使用本文提出的指纹IC卡暂住人口身份证管理系统,可以使被查者与本人身份完全一致,能够强化暂住人口的管理. 相似文献
2.
Krantz ID McCallum J DeScipio C Kaur M Gillis LA Yaeger D Jukofsky L Wasserman N Bottani A Morris CA Nowaczyk MJ Toriello H Bamshad MJ Carey JC Rappaport E Kawauchi S Lander AD Calof AL Li HH Devoto M Jackson LG 《Nature genetics》2004,36(6):631-635
Cornelia de Lange syndrome (CdLS; OMIM 122470) is a dominantly inherited multisystem developmental disorder characterized by growth and cognitive retardation; abnormalities of the upper limbs; gastroesophageal dysfunction; cardiac, ophthalmologic and genitourinary anomalies; hirsutism; and characteristic facial features. Genital anomalies, pyloric stenosis, congenital diaphragmatic hernias, cardiac septal defects, hearing loss and autistic and self-injurious tendencies also frequently occur. Prevalence is estimated to be as high as 1 in 10,000 (ref. 4). We carried out genome-wide linkage exclusion analysis in 12 families with CdLS and identified four candidate regions, of which chromosome 5p13.1 gave the highest multipoint lod score of 2.7. This information, together with the previous identification of a child with CdLS with a de novo t(5;13)(p13.1;q12.1) translocation, allowed delineation of a 1.1-Mb critical region on chromosome 5 for the gene mutated in CdLS. We identified mutations in one gene in this region, which we named NIPBL, in four sporadic and two familial cases of CdLS. We characterized the genomic structure of NIPBL and found that it is widely expressed in fetal and adult tissues. The fly homolog of NIPBL, Nipped-B, facilitates enhancer-promoter communication and regulates Notch signaling and other developmental pathways in Drosophila melanogaster. 相似文献
3.
4.
W. Sandritter H. Diefenbach F. Krantz 《Cellular and molecular life sciences : CMLS》1954,10(5):210-212
Summary It is shown that the dye gallocyaninchromalum combines quantitatively with ribonucleic acid. 1 molecule gallocyanin is equivalent to approximately 15 phosphorus atoms. The quantitative combinationin vitro is not disturbed by proteins.
Ausgeführt mit Mitteln der Deutschen Forschungsgemeinschaft. 相似文献
Ausgeführt mit Mitteln der Deutschen Forschungsgemeinschaft. 相似文献
5.
6.
Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis
Lee YC Kuo HC Chang JS Chang LY Huang LM Chen MR Liang CD Chi H Huang FY Lee ML Huang YC Hwang B Chiu NC Hwang KP Lee PC Chang LC Liu YM Chen YJ Chen CH;Taiwan Pediatric ID Alliance Chen YT Tsai FJ Wu JY 《Nature genetics》2012,44(5):522-525
To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10(-8)). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis. 相似文献
7.
8.
G. W. Krantz 《Journal of Natural History》2016,50(29-30):1797-1812
Decomposing beach wrack in a backwater of Yaquina Bay, Oregon, was found to contain nymphs and adults of a previously undescribed species of the mite genus Halolaelaps (Halolaelapidae). Significant variation was noted among available specimens in the number of opisthonotal shield setae, a feature that has long been considered to be of critical importance in identifying celticus group species. The presence of a well-formed posterodorsal cribrum in this and related celticus group species prompted an examination of cribral development in the Halolaelapidae as a whole and revealed that posterodorsal cribral elements occur in various configurations in three of the four presently recognized halolaelapid genera. A narrow, transversely oriented configuration appears to be unique to members of the celticus species group. 相似文献
9.
Until recently, the expression and primary function of the cell surface receptor CD40 and its ligand CD154 were considered
restricted to B and T lymphocytes, and their interactions required for the thymus-dependent humoral response. However, current
work from several groups challenges this view of the CD40/CD154 dyad as a mere mediator of lymphocyte communication. A variety
of non-lymphocytic cell types express both receptor and ligand, including hematopoetic and non-hematopoetic cells, such as
monocytes, basophils, eosinophils, dendritic cells, fibroblasts, smooth muscle, and endothelial cells. Accordingly, ligation
of CD40 mediates a broad variety of immune and inflammatory responses, such as the expression of adhesion molecules, cytokines,
matrix-degrading enzymes, prothrombotic activities, and apoptotic mediators. Consequently, CD40 signaling has been associated
with pathogenic processes of chronic inflammatory diseases, such as autoimmune diseases, neurodegenerative disorders, graft-versus-host
disease, cancer, and atherosclerosis. This review focuses on the synthesis and structure of CD40 and outlines CD154/CD40 signaling
pathways, and emphasizes the previously unexpected importance of the CD40/CD154 receptor/ligand dyad in a spectrum of immunoregulatory
processes and prevalent human diseases.
Received 10 January 2000; revised 16 June 2000; accepted 5 July 2000
RID="†"
ID="†" Review
RID="*"
ID="*" Corresponding author. 相似文献
10.
Tomasz Marquardt Sławomir Kaczmarek Gerald W. Krantz 《Journal of Natural History》2016,50(23-24):1473-1482
Egg deposition by the soil mites Lasioseius ometes (Oudemans, 1903) and Hypoaspis kargi Costa, 1968 was observed using continuous video-monitoring. The process in both species was found to consist of four distinct phases. In Phase 1, both species engage in pre-ovipositional activity prior to the egg being extruded from the genital opening. In L. ometes, the female often selects a substrate depression for egg laying and examines the depression carefully with the gnathosoma and legs I before oviposition. In H. kargi, egg deposition sites are chosen without regard for substrate depressions. Phase 1 lasted approximately 3 minutes for both species. Phase 2 involved egg extrusion and holding of the egg beneath the gnathosoma. Phase 2 lasted approximately 20 times longer in L. ometes (5 minutes) than in H. kargi. Alteration of the egg surface in the form of thorn-like outgrowths was recorded in L. ometes. Egg deposition occurs in Phase 3, and in L. ometes the egg is generally placed at the deposition site using the chelicerae. Hypoaspis kargi also uses the chelicerae for egg manipulation, but also adjusts orientation of the egg with legs I. The sticky nature of egg surface in H. kargi may provide a means for the female to effectively cover the exposed egg with a protective layer of soil particles. Egg deposition in both species occurred in less than 90 seconds. Phase 4 involves egg covering, but behaviour of the female during this last phase differs markedly between the two species. In L. ometes, the female tends to remain close to the egg, whereas in H. kargi the female moves away from the egg to search for substrate particles appropriate for its covering. The average time for Phase 4 in H. kargi was approximately four times longer (80+ minutes) than in L. ometes. 相似文献