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在数位化与网路化的学术典藏传播大趋势下 ,建构一个完整、方便、迅速与合理使用的校园数位内容经营服务体系 ,是兼具教育与研究两大使命的大学机构必须进行的工作 ,特别是对身负知识典藏与传播责任的图书馆来说 ,更是刻不容缓的任务 .本文介绍逢甲大学图书馆所规划推动的校园数位内容经营服务管理计画 ,探讨其征集服务范围以及提交、互评、加值典藏、传播与版权管理等作业流程 ,并说明所需要的支援团队和人力配置、所产出的产品形式和应用方式 .最后从著作权的角度分析校园数位内容经营服务所涉及的合理使用、著作财产权和著作授权使用问题 相似文献
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Jieting Zhang Yan Wang Xiaohua Jiang Hsiao Chang Chan 《Cellular and molecular life sciences : CMLS》2018,75(10):1737-1756
Mutations of cystic fibrosis transmembrane conductance regulator (CFTR) cause cystic fibrosis, the most common life-limiting recessive genetic disease among Caucasians. CFTR mutations have also been linked to increased risk of various cancers but remained controversial for a long time. Recent studies have begun to reveal that CFTR is not merely an ion channel but also an important regulator of cancer development and progression with multiple signaling pathways identified. In this review, we will first present clinical findings showing the correlation of genetic mutations or aberrant expression of CFTR with cancer incidence in multiple cancers. We will then focus on the roles of CFTR in fundamental cellular processes including transformation, survival, proliferation, migration, invasion and epithelial–mesenchymal transition in cancer cells, highlighting the signaling pathways involved. Finally, the association of CFTR expression levels with patient prognosis, and the potential of CFTR as a cancer prognosis indicator in human malignancies will be discussed. 相似文献
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Horvath A Boikos S Giatzakis C Robinson-White A Groussin L Griffin KJ Stein E Levine E Delimpasi G Hsiao HP Keil M Heyerdahl S Matyakhina L Libè R Fratticci A Kirschner LS Cramer K Gaillard RC Bertagna X Carney JA Bertherat J Bossis I Stratakis CA 《Nature genetics》2006,38(7):794-800
Phosphodiesterases (PDEs) regulate cyclic nucleotide levels. Increased cyclic AMP (cAMP) signaling has been associated with PRKAR1A or GNAS mutations and leads to adrenocortical tumors and Cushing syndrome. We investigated the genetic source of Cushing syndrome in individuals with adrenocortical hyperplasia that was not caused by known defects. We performed genome-wide SNP genotyping, including the adrenocortical tumor DNA. The region with the highest probability to harbor a susceptibility gene by loss of heterozygosity (LOH) and other analyses was 2q31-2q35. We identified mutations disrupting the expression of the PDE11A isoform-4 gene (PDE11A) in three kindreds. Tumor tissues showed 2q31-2q35 LOH, decreased protein expression and high cyclic nucleotide levels and cAMP-responsive element binding protein (CREB) phosphorylation. PDE11A codes for a dual-specificity PDE that is expressed in adrenal cortex and is partially inhibited by tadalafil and other PDE inhibitors; its germline inactivation is associated with adrenocortical hyperplasia, suggesting another means by which dysregulation of cAMP signaling causes endocrine tumors. 相似文献
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Su HT Hsu RR Chen AB Wang YC Hsiao WS Lai WC Lee LC Sato M Fukunishi H 《Nature》2003,423(6943):974-976
Transient luminous events in the atmosphere, such as lighting-induced sprites and upwardly discharging blue jets, were discovered recently in the region between thunderclouds and the ionosphere. In the conventional picture, the main components of Earth's global electric circuit include thunderstorms, the conducting ionosphere, the downward fair-weather currents and the conducting Earth. Thunderstorms serve as one of the generators that drive current upward from cloud tops to the ionosphere, where the electric potential is hundreds of kilovolts higher than Earth's surface. It has not been clear, however, whether all the important components of the global circuit have even been identified. Here we report observations of five gigantic jets that establish a direct link between a thundercloud (altitude approximately 16 km) and the ionosphere at 90 km elevation. Extremely-low-frequency radio waves in four events were detected, while no cloud-to-ground lightning was observed to trigger these events. Our result indicates that the extremely-low-frequency waves were generated by negative cloud-to-ionosphere discharges, which would reduce the electrical potential between ionosphere and ground. Therefore, the conventional picture of the global electric circuit needs to be modified to include the contributions of gigantic jets and possibly sprites. 相似文献
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A potentially powerful information processing strategy in the brain is to take advantage of the temporal structure of neuronal spike trains. An increase in synchrony within the neural representation of an object or location increases the efficacy of that neural representation at the next synaptic stage in the brain; thus, increasing synchrony is a candidate for the neural correlate of attentional selection. We investigated the synchronous firing of pairs of neurons in the secondary somatosensory cortex (SII) of three monkeys trained to switch attention between a visual task and a tactile discrimination task. We found that most neuron pairs in SII cortex fired synchronously and, furthermore, that the degree of synchrony was affected by the monkey's attentional state. In the monkey performing the most difficult task, 35% of neuron pairs that fired synchronously changed their degree of synchrony when the monkey switched attention between the tactile and visual tasks. Synchrony increased in 80% and decreased in 20% of neuron pairs affected by attention. 相似文献
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本文利用描述喷吹钢包内流动现象的全浮力模型及其提供的边界条件,建立轴对称循环流场的数学模型。利用以速度和压力为主要因变量的微分方程组和Κ-ε双方程湍流模型来描述流体流动,用SIMPLER法数值求解。将所得结果与相同喷吹条件下的激光测速仪测量值对比,两者吻合较好。由数学模型预示的混匀时间与全浮力模型公式计算值和示踪剂实测值相近。 相似文献
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Howell DA Sullivan M Nugent PE Ellis RS Conley AJ Le Borgne D Carlberg RG Guy J Balam D Basa S Fouchez D Hook IM Hsiao EY Neill JD Pain R Perrett KM Pritchet CJ 《Nature》2006,443(7109):308-311
The accelerating expansion of the Universe, and the need for dark energy, were inferred from observations of type Ia supernovae. There is a consensus that type Ia supernovae are thermonuclear explosions that destroy carbon-oxygen white dwarf stars that have accreted matter from a companion star, although the nature of this companion remains uncertain. These supernovae are thought to be reliable distance indicators because they have a standard amount of fuel and a uniform trigger: they are predicted to explode when the mass of the white dwarf nears the Chandrasekhar mass of 1.4 solar masses (M(o)). Here we show that the high-redshift supernova SNLS-03D3bb has an exceptionally high luminosity and low kinetic energy that both imply a super-Chandrasekhar-mass progenitor. Super-Chandrasekhar-mass supernovae should occur preferentially in a young stellar population, so this may provide an explanation for the observed trend that overluminous type Ia supernovae occur only in 'young' environments. As this supernova does not obey the relations that allow type Ia supernovae to be calibrated as standard candles, and as no counterparts have been found at low redshift, future cosmology studies will have to consider possible contamination from such events. 相似文献
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利用特殊的四边形夹具可分别施加等值的拉、压载荷,同时测出拉、压应力引起的相对稳态氢渗透通量的变化就可求出氢的应变场。结果表明,氢在铁中的应变场是非球对称的,且;ε_1>0,ε_2=ε_3<0。 实验表明,氢的表观偏克原子应变场和表观偏克原子体积均随体内氢浓度的增加而下降。用最小二乘法可获得氢浓度趋于零时的真实值,分别为ε_1=0.37,ε_2=ε_3=-0.11,V_H=2.49cm~3/mol。实验还表明,外加应力大小对应变场没有影响。 相似文献
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Li-Chun Wang Kuan-Yu Chen Huichin Pan Chia-Chieh Wu Po-Hsuan Chen Yuan-Ting Liao Chin Li Min-Lang Huang Kuang-Ming Hsiao 《Cellular and molecular life sciences : CMLS》2011,68(7):1255-1267
We have utilized Caenorhabditis elegans as a model to investigate the toxicity and underlying mechanism of untranslated CAG repeats in comparison to CUG repeats.
Our results indicate that CAG repeats can be toxic at the RNA level in a length-dependent manner, similar to that of CUG repeats.
Both CAG and CUG repeats of toxic length form nuclear foci and co-localize with C. elegans muscleblind (CeMBL), implying that CeMBL may play a role in repeat RNA toxicity. Consistently, the phenotypes of worms expressing
toxic CAG and CUG repeats, including shortened life span and reduced motility rate, were partially reversed by CeMbl over-expression. These results provide the first experimental evidence to show that the RNA toxicity induced by expanded
CAG and CUG repeats can be mediated, at least in part, through the functional alteration of muscleblind in worms. 相似文献