基于土性相关蒙特卡罗法的争岗滑坡堆积体可靠性分析

针对澜沧江古水水电站争岗滑坡堆积体工程地质务件,在室内剪切试验、工程类比、参数反演基础上综合确定了岩土体力学参数及其统计分布规律.采用基于黏聚力c与内摩擦角φ相关抽样下的蒙特卡罗法对堆积体典型剖面进行了多种工况下的可靠性分析,预测了其未来的变形失稳特征.研究结果表明:当前堆积体B-B'剖面在正常运行工况下的破坏概率为2...     

Interferon-γ links ultraviolet radiation to melanomagenesis in mice

Cutaneous malignant melanoma is a highly aggressive and frequently chemoresistant cancer, the incidence of which continues to rise. Epidemiological studies show that the major aetiological melanoma risk factor is ultraviolet (UV) solar radiation, with the highest risk associated with intermittent burning doses, especially during childhood. We have experimentally validated these epidemiological findings using the hepatocyte growth factor/scatter factor transgenic mouse model, which develops lesions in stages highly reminiscent of human melanoma with respect to biological, genetic and aetiological criteria, but only when irradiated as neonatal pups with UVB, not UVA. However, the mechanisms underlying UVB-initiated, neonatal-specific melanomagenesis remain largely unknown. Here we introduce a mouse model permitting fluorescence-aided melanocyte imaging and isolation following in vivo UV irradiation. We use expression profiling to show that activated neonatal skin melanocytes isolated following a melanomagenic UVB dose bear a distinct, persistent interferon response signature, including genes associated with immunoevasion. UVB-induced melanocyte activation, characterized by aberrant growth and migration, was abolished by antibody-mediated systemic blockade of interferon-γ (IFN-γ), but not type-I interferons. IFN-γ was produced by macrophages recruited to neonatal skin by UVB-induced ligands to the chemokine receptor Ccr2. Admixed recruited skin macrophages enhanced transplanted melanoma growth by inhibiting apoptosis; notably, IFN-γ blockade abolished macrophage-enhanced melanoma growth and survival. IFN-γ-producing macrophages were also identified in 70% of human melanomas examined. Our data reveal an unanticipated role for IFN-γ in promoting melanocytic cell survival/immunoevasion, identifying a novel candidate therapeutic target for a subset of melanoma patients.     

核能谱与两类转动惯量的精确表达式

用最小二乘拟合法,将稀土区的能谱实验数据,拟合不同的能谱公式,从而证明E=a〔(1+bI(I+1))~(1/2)-1〕是符合得较好的,本文还推导了与上述能谱相应的两类转动惯量,并以此与实验计算值进行比较,结果仍很满意.     

Accelerated carbonation and leaching behavior of the slag from iron and steel making industry

Ground granulated blast furnace slag(GGBFS)and steelmaking slag have been used as a raw material for cement production or as an aggregate to make concrete,which contribute aluminum,calcium,iron,and silicon oxides.The suitability of the slag for a particular application depends on its reactivity,cost,availability,and its influence on the properties of the resulting concrete.For the interest of durability studying of concrete in the presence of slag,the accelerated carbonation products and leaching behavior of the slag and Portland cement(PC)were studied.The experimental results confirmed that the slag was more resistant to carbonation compared to PC.The carbonation degree of GGBFS reduced by 17.74%;and the carbonation degrees of steelmaking slags reduced by 9.51%-11.94%.Carbonation neutralized the alkaline nature of the hydrated pastes and gave rise to the redox potential of the leachate slightly(30-77 mV).The carbonation also increased the release of most of the elements presented,except for calcium,to the aqueous environment.It is concluded that blend cements(PC plus slag)have economical advantages and better durability compared to PC.     

基于稳健波束形成的超宽带穿墙成像方法

针对现有超宽带穿墙雷达时域波束成像分辨率低、旁瓣高以及干扰抑制能力弱等问题,提出利用稳健Capon波束形成对目标成像的方法。该方法基于目标回波模型首先补偿近场扩散损耗、墙体传播损耗和折射效应,实现天线阵列接收数据的配准,利用稳健Capon波束成像得到良好的成像分辨率和更好的干扰抑制能力。利用时域有限差分(finite-difference time domain, FDTD)数值仿真和实验数据实现了隐藏目标的二维成像,验证了该方法的有效性。     

热局部非平衡下饱和多孔弹性柱体的拟静态分析

基于多孔介质理论所建立的不可压饱和多孔介质热一流一同耦合模型,对于一端同定、绝热和不可渗透,另一端受机械和温度载荷联合作用且可自由排水的多孔弹性柱体,利用分离变量法和拉普拉斯变换推导给出了热局部非平衡下多孑L弹性柱体拟静态问题的一般解析表达式.最后,针对阶梯机械和温度载荷联合作用的情况,数值研究了不同参数下温度载荷对固相变形和有效应力、流体速度和孔隙压力的影响.结果表明:在流固两相热扩散系数的比值较大和两相间热交换系数比较小的情况下,热局部平衡和非平衡下有关结果之间的差异在初始阶段是非常明显的.     

高炉渣合成Ca-α-Sialon-SiC粉的热力学分析及工艺优化

在热力学分析的基础上，以高炉渣为原料，引入适当的添加剂，利用碳热还原－氮化的方法制备了Ｃａ－α－Ｓｉａｌｏｎ－ＳｉＣ粉，得到的Ｃａ－α－Ｓｉａｌｏｎ含量最高可以达到８１％；利用统计模式识别结合人工神经元网络优化了工艺．     

Room-temperature ferroelectricity in strained SrTiO3

Systems with a ferroelectric to paraelectric transition in the vicinity of room temperature are useful for devices. Adjusting the ferroelectric transition temperature (T(c)) is traditionally accomplished by chemical substitution-as in Ba(x)Sr(1-x)TiO(3), the material widely investigated for microwave devices in which the dielectric constant (epsilon(r)) at GHz frequencies is tuned by applying a quasi-static electric field. Heterogeneity associated with chemical substitution in such films, however, can broaden this phase transition by hundreds of degrees, which is detrimental to tunability and microwave device performance. An alternative way to adjust T(c) in ferroelectric films is strain. Here we show that epitaxial strain from a newly developed substrate can be harnessed to increase T(c) by hundreds of degrees and produce room-temperature ferroelectricity in strontium titanate, a material that is not normally ferroelectric at any temperature. This strain-induced enhancement in T(c) is the largest ever reported. Spatially resolved images of the local polarization state reveal a uniformity that far exceeds films tailored by chemical substitution. The high epsilon(r) at room temperature in these films (nearly 7,000 at 10 GHz) and its sharp dependence on electric field are promising for device applications.