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Movement of internalized ligand-receptor complexes along a continuous endosomal reticulum 总被引:63,自引:0,他引:63
Complexes of cell-surface receptors and their ligands are commonly internalized by endocytosis and enter a prelysosomal endosomal pathway for further processing. Fluorescence microscopy and video recording of living cells to trace the passage of ligand-receptor complexes has identified the endosomal compartment as an extensive network of tubular cisternae. Endocytosed material entering this reticulum enters discrete swellings, identified as multivesicular bodies by electron microscopy, which move along the reticulum towards the pericentriolar area. 相似文献
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J. B. Gibson A. V. Wilks G. K. Chambers 《Cellular and molecular life sciences : CMLS》1982,38(6):653-654
Summary A 3rd allele at theAdh locus,Adh
FCh.D., has been found at polymorphic frequencies in natural populations ofD. melanogaster. The ADH-FChD enzyme has properties distinct from those of the 2 more common forms of ADH. TheAdh polymorphism should now be analyzed as a triallelic system. 相似文献
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P Anand S J Gibson G P McGregor M A Blank M A Ghatei A J Bacarese-Hamilton J M Polak S R Bloom 《Nature》1983,305(5930):143-145
Neuropeptides were first localized in the human spinal cord by immunocytochemistry and substance P has been shown, by the same method, to be reduced ipsilaterally in the dorsal horn after limb amputation and bilaterally in the Riley-Day syndrome. Several neuropeptides increasingly fulfil the criteria to establish them as neurotransmitters or neuromodulators, and they may also have trophic actions in the spinal cord. Using radioimmunoassay and immunocytochemistry, we present here for the first time a quantitative regional distribution and localization of vasoactive intestinal polypeptide (VIP), substance P, somatostatin, bombesin and cholecystokinin (CCK-8) in normal postmortem human spinal cord. A comparison of the distribution of these peptides reveals an exceptional pattern for VIP, with relatively much higher levels in the lumbosacral region. Immunocytochemical analysis shows a distinctive distribution of VIP-containing fibres and terminals at the lumbosacral segments. This VIP-containing system may have an important role in the spinal control of urogenital function in man. 相似文献
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Rats are shown to acquire a preference for protein-predictive olfactory cues which depends on a state of mild deficit in protein intake--i.e. a learned protein-specific appetite. 相似文献
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DNA sequence and expression of the B95-8 Epstein-Barr virus genome 总被引:34,自引:0,他引:34
R Baer A T Bankier M D Biggin P L Deininger P J Farrell T J Gibson G Hatfull G S Hudson S C Satchwell C Séguin 《Nature》1984,310(5974):207-211
The complete (172,282 base pairs) nucleotide sequence of the B95-8 strain of Epstein-Barr virus has been established using the dideoxynucleotide/M13 sequencing procedure. Many RNA polymerase II promoters have been mapped and the mRNAs from these promoters have been assigned to the latent or early/late productive virus cycles. Likely protein-coding regions have been identified and three of these have been shown to encode a ribonucleotide reductase, a DNA polymerase and two surface glycoproteins. 相似文献
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J. B. Gibson 《Cellular and molecular life sciences : CMLS》1972,28(8):975-976
Résumé Les techniques immunologiques ont démontré que chezDrosophila melanogaster une forme électrophorétique «Fast» d'alcool déshydrogénase produit plus de molécules d'enzyme qu'une forme électrophorétique Slow. On expose les résultats en les comparant à d'autres suggérant des mécanismes autorégulatoire.
Acknowledgement. I am grateful to Dr.D. Roberts for helpful discussions. 相似文献
Acknowledgement. I am grateful to Dr.D. Roberts for helpful discussions. 相似文献
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