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Identification and mapping to chromosome 1 of a susceptibility locus for periinsulitis in non-obese diabetic mice 总被引:11,自引:0,他引:11
Insulin-dependent diabetes mellitus (IDDM) is a polygenic disease caused by autoimmune destruction of insulin-producing beta cells in the islets of Langerhans. Its onset is preceded by a long and variable period in which lymphoid cells infiltrate the pancreas but first remain outside the islets (peri-insulitis) before invading them (insulitis). Among susceptibility loci, only the major histocompatibility complex (MHC) has been clearly assigned. Genetic study of the nonobese diabetic (NOD) mouse model for insulin-dependent diabetes mellitus has revealed genetic linkage of insulitis and of early onset diabetes with two non-MHC loci mapping to chromosome 3 and 11 respectively. Here we report a close association of periinsulitis with a third non-MHC locus mapping to chromosome 1. Successive stages in the progression of diabetic disease thus appear to be controlled by distinct genes or sets of genes. 相似文献
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本文较深入地研究了脱硫石膏粉煤灰化学成分、杂质、颗粒特征和激发剂等对脱硫石膏、粉煤灰胶结材性能的影响 研究表明 ,激发剂是影响脱硫石膏、粉煤灰胶结材性能的主要因素 这为脱硫石膏、粉煤灰资源化利用打下良好理论基础 经实际应用表明 ,研究结果与实际情况能很好相符 相似文献
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介绍用计算机软件产生正弦稳态扫频信号的编程方法。通过对D/A变换与A/D采集的同步输出可以获得不同频率量程和设定电压的扫频输出 相似文献
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A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes 总被引:23,自引:0,他引:23
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一类高阶非线性系统的零解稳定性 总被引:1,自引:0,他引:1
由Барбащин公式得到的四阶常系数线性系统的Ляпунов函数出发,通过类比法构造了一类四阶非线性系统的Ляпунов函数,并由此得到了这些系统零解的全局渐近稳定性的充分条件 相似文献
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