全文获取类型
收费全文 | 153篇 |
免费 | 0篇 |
国内免费 | 1篇 |
专业分类
丛书文集 | 2篇 |
理论与方法论 | 2篇 |
现状及发展 | 53篇 |
研究方法 | 13篇 |
综合类 | 82篇 |
自然研究 | 2篇 |
出版年
2012年 | 2篇 |
2011年 | 10篇 |
2010年 | 1篇 |
2009年 | 1篇 |
2008年 | 8篇 |
2007年 | 6篇 |
2006年 | 9篇 |
2005年 | 4篇 |
2004年 | 5篇 |
2003年 | 5篇 |
2002年 | 4篇 |
2001年 | 5篇 |
2000年 | 5篇 |
1999年 | 1篇 |
1995年 | 1篇 |
1992年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 6篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1980年 | 1篇 |
1979年 | 3篇 |
1978年 | 9篇 |
1977年 | 1篇 |
1976年 | 5篇 |
1974年 | 5篇 |
1973年 | 2篇 |
1972年 | 3篇 |
1971年 | 15篇 |
1970年 | 8篇 |
1969年 | 9篇 |
1968年 | 3篇 |
1967年 | 1篇 |
1966年 | 2篇 |
1965年 | 1篇 |
1964年 | 2篇 |
1963年 | 2篇 |
1958年 | 1篇 |
排序方式: 共有154条查询结果,搜索用时 31 毫秒
1.
催化动力学测定痕量钴研究综述 总被引:1,自引:0,他引:1
综述了近年来催化动力学光度法测定痕量钴的进展情况。对催化显色动力学光度法、催化褪色动力学光度法、催化荧光光度法、阻抑动力学光度法、催化化学发光光度法等几个类别,从反应介质、灵敏度、线性范围等方面介绍了对不同反应体系的研究情况,并对催化动力学光度法测定痕量钴的发展趋势做出预测。 相似文献
2.
薛文海 《科技情报开发与经济》2011,21(10):216-218
介绍了路基施工高边坡开挖安全措施,包括健全安全管理组织机构、施工安全措施、高空作业安全措施、机械作业安全措施等。 相似文献
3.
The enzyme uracil DNA glycosylase (UNG) excises unwanted uracil bases in the genome using an extrahelical base recognition mechanism. Efficient removal of uracil is essential for prevention of C-to-T transition mutations arising from cytosine deamination, cytotoxic U*A pairs arising from incorporation of dUTP in DNA, and for increasing immunoglobulin gene diversity during the acquired immune response. A central event in all of these UNG-mediated processes is the singling out of rare U*A or U*G base pairs in a background of approximately 10(9) T*A or C*G base pairs in the human genome. Here we establish for the human and Escherichia coli enzymes that discrimination of thymine and uracil is initiated by thermally induced opening of T*A and U*A base pairs and not by active participation of the enzyme. Thus, base-pair dynamics has a critical role in the genome-wide search for uracil, and may be involved in initial damage recognition by other DNA repair glycosylases. 相似文献
4.
Gene duplication and loss is a powerful source of functional innovation. However, the general principles that govern this process are still largely unknown. With the growing number of sequenced genomes, it is now possible to examine these events in a comprehensive and unbiased manner. Here, we develop a procedure that resolves the evolutionary history of all genes in a large group of species. We apply our procedure to seventeen fungal genomes to create a genome-wide catalogue of gene trees that determine precise orthology and paralogy relations across these species. We show that gene duplication and loss is highly constrained by the functional properties and interacting partners of genes. In particular, stress-related genes exhibit many duplications and losses, whereas growth-related genes show selection against such changes. Whole-genome duplication circumvents this constraint and relaxes the dichotomy, resulting in an expanded functional scope of gene duplication. By characterizing the functional fate of duplicate genes we show that duplicated genes rarely diverge with respect to biochemical function, but typically diverge with respect to regulatory control. Surprisingly, paralogous modules of genes rarely arise, even after whole-genome duplication. Rather, gene duplication may drive the modularization of functional networks through specialization, thereby disentangling cellular systems. 相似文献
5.
6.
Michael Friedman 《Studies in history and philosophy of science》2012,43(1):47-53
I address the points raised by the four commentators by indicating how I have been thinking about extending and expanding my perspective since Dynamics of Reason (2001). This involves reinterpreting the Kantian distinction between understanding and sensibility, and thereby rethinking the relativized a priori. I connect these ideas with experimental contexts and technology, as well as with the wider culture context. I suggest implications for the relationships among science, democracy, and religion—and eventually reconceptualizing Kant’s original Enlightenment project. 相似文献
7.
8.
Jean-Pierre Vilardaga Guillermo Romero Peter A. Friedman Thomas J. Gardella 《Cellular and molecular life sciences : CMLS》2011,68(1):1-13
The parathyroid hormone (PTH) receptor type 1 (PTHR), a G protein-coupled receptor (GPCR), transmits signals to two hormone
systems—PTH, endocrine and homeostatic, and PTH-related peptide (PTHrP), paracrine—to regulate different biological processes.
PTHR responds to these hormonal stimuli by activating heterotrimeric G proteins, such as GS that stimulates cAMP production. It was thought that the PTHR, as for all other GPCRs, is only active and signals through
G proteins on the cell membrane, and internalizes into a cell to be desensitized and eventually degraded or recycled. Recent
studies with cultured cell and animal models reveal a new pathway that involves sustained cAMP signaling from intracellular
domains. Not only do these studies challenge the paradigm that cAMP production triggered by activated GPCRs originates exclusively
at the cell membrane but they also advance a comprehensive model to account for the functional differences between PTH and
PTHrP acting through the same receptor. 相似文献
9.
M. A. Friedman E. Arnold Y. Bishop Dr. S. S. Epstein 《Cellular and molecular life sciences : CMLS》1971,27(9):1052-1054
Zusammenfassung Piperonylbutoxyd, Methylendioxylanilin, Methyleugenol, Safranol und Vanillylamin bewirken eine additive Hemmung der Funktion mikrosomaler Enzyme in Mäusen, wenn sie zusammen in Dosen verabreicht werden, die einzeln inaktiv sind. Piperonylbutoxyd und Safranol induzieren synergistisch die Hemmung von Aminopyrenedemethylase-Aktivität. Es erfolgte keine synergistische Hemmung nach kombinierter Behandlung mit Pib. und hohen Dosen der strukturell verwandten, aber inaktiven Piperonylsäure.
Supported by N.I.H. Grants No. C-6516 and No. Fr-05526.
We thank Mrs.M. Sengupta and Mr.E. Greene for their technical assistance. 相似文献
Supported by N.I.H. Grants No. C-6516 and No. Fr-05526.
We thank Mrs.M. Sengupta and Mr.E. Greene for their technical assistance. 相似文献
10.