排序方式: 共有16条查询结果,搜索用时 15 毫秒
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Suhre K Shin SY Petersen AK Mohney RP Meredith D Wägele B Altmaier E;CARDIoGRAM Deloukas P Erdmann J Grundberg E Hammond CJ de Angelis MH Kastenmüller G Köttgen A Kronenberg F Mangino M Meisinger C Meitinger T Mewes HW Milburn MV Prehn C Raffler J Ried JS Römisch-Margl W Samani NJ Small KS Wichmann HE Zhai G Illig T Spector TD Adamski J Soranzo N Gieger C 《Nature》2011,477(7362):54-60
Genome-wide association studies (GWAS) have identified many risk loci for complex diseases, but effect sizes are typically small and information on the underlying biological processes is often lacking. Associations with metabolic traits as functional intermediates can overcome these problems and potentially inform individualized therapy. Here we report a comprehensive analysis of genotype-dependent metabolic phenotypes using a GWAS with non-targeted metabolomics. We identified 37 genetic loci associated with blood metabolite concentrations, of which 25 show effect sizes that are unusually high for GWAS and account for 10-60% differences in metabolite levels per allele copy. Our associations provide new functional insights for many disease-related associations that have been reported in previous studies, including those for cardiovascular and kidney disorders, type 2 diabetes, cancer, gout, venous thromboembolism and Crohn's disease. The study advances our knowledge of the genetic basis of metabolic individuality in humans and generates many new hypotheses for biomedical and pharmaceutical research. 相似文献
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J. Heidenreich W. Erdmann H. Metzger G. Thews 《Cellular and molecular life sciences : CMLS》1970,26(3):257-259
Résumé La pression partielle de l'oxygène et la «clearance» de l'hydrogène ont été mesurées dans des régions circonscrites. Les deux valeurs sont enregistrées par la même microélectrode de platine (diamètre de la pointe 10). Cette méthode nouvelle est appliquée dans des expériences faites sur le cerveau de Rats narcotisés et on est capable d'évaluer les inhomogénités locales de l'apport d'oxygène dépendant du flux du sang. 相似文献
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Osteoarthritis has developed into the most common chronic disease in the highly industrialized nations. Moreover, because
of the prevalence of the disease in the elderly, this trend occurs worldwide as a consequence of increasing longevity due
to the overall improvement in living conditions and health status. In contrast, research on osteoarthritis is still financially
marginalized within biomedical research, so that the molecular and biophysical bases for disease initiation and progression
are largely unmapped. The following sequence of five reviews highlights a remarkable change in that body of knowledge taking
place at the beginning of the World Health Organization (WHO) 'Bone and Joint Decade 2001-2010'. The data and ideas presented
in these articles reflect to some extent the guidelines set up by the WHO and by the National Institutes of Health of the
USA and therefore allow a glimpse into the directions that research in osteoarthritis will take in the future. 相似文献
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