排序方式: 共有18条查询结果,搜索用时 15 毫秒
1.
Untangling the molecular nature of sperm-egg interactions is fundamental if we are to understand fertilization. These phenomena
have been studied for many years using biochemical approaches such as antibodies and ligands that interact with sperm or with
eggs and their vestments. However, when homologous genetic recombination techniques were applied, most of the phenotypic factors
of the gene-manipulated animals believed “essential” for fertilization were found to be dispensable. Of course, all biological
systems contain redundancies and compensatory mechanisms, but as a whole the old model of fertilization clearly requires significant
modification. In this review, we use the results of gene manipulation experiments in animals to propose the basis for a new
vision.
Received 26 January 2007; received after revision 7 March 2007; accepted 17 April 2007 相似文献
2.
3.
Nathan W. Cummins Andrew D. Badley 《Cellular and molecular life sciences : CMLS》2013,70(18):3355-3363
Past efforts at curing infection with the human immunodeficiency virus (HIV) have been blocked by the resistance of some infected cells to viral cytopathic effects and the associated development of a latent viral reservoir. Furthermore, current efforts to clear the viral reservoir by means of reactivating latent virus are hampered by the lack of cell death in the newly productively infected cells. The purpose of this review is to describe the many anti-apoptotic mechanisms of HIV, as well as the current limitations in the field. Only by understanding how infected cells avoid HIV-induced cell death can an effective strategy to kill infected cells be developed. 相似文献
4.
D. J. Simmons R. Hakim H. Cummins 《Cellular and molecular life sciences : CMLS》1971,27(10):1210-1211
Résumé Sur les cartilages de conjugaison de souris adulte, on a mesuré par une méthode histologique l'effet de grandes doses de rayonnements béta de90Sr-90Y appliquées à 68 rads/h pendants 11–16 h. Après l'irradiation, les changements d'épaisseur du cartilage ont suggeré un modèle de dommages et de récupération qui ressembla à une réponse adaptive aux expositions unique de l'X-irradiation.
This work was performed under the auspices of the U.S. Atomic Energy Commission. 相似文献
This work was performed under the auspices of the U.S. Atomic Energy Commission. 相似文献
5.
The forefront of research into the complexes of uranium reveals chemical transformations that challenge and expand our view of this unique element. Certain ligands form multiple bonds to uranium, and small, inert molecules such as nitrogen and carbon dioxide become reactive when in complex with the metal. Such complexes provide clues to the catalytic future of uranium, in which the applications of the element extend far beyond the nuclear industry. Most excitingly, the ability of uranium to use its outermost f electrons for binding ligands might enable the element to catalyse reactions that are impossible with conventional, transition-metal catalysts. 相似文献
6.
7.
8.
Environmentally-induced changes in the brains of elderly rats 总被引:1,自引:0,他引:1
9.
10.
A first step towards somatic hybridization in plants has been achieved. Protoplasts have been isolated and seen to fuse. 相似文献