潜力巨大的银发市场——无障碍车商机无限

随着发达国家的人口逐渐老化,对年长车主与残疾车主的关注也逐渐上升。日本是全世界国民平均寿命最长的国家,日本车厂对人口老龄化相关课题的重视自然超过其它竞争对手,日产车厂甚至拥有一个超过700人的团队专门研究年长车主的需求。2004年东京车展就以“关怀弱势车主”为展览主题,我们来看看日产、丰田、本田、马自达、斯巴鲁与三菱在内的日本车厂最新的研究成果     

Potentiation of the cerebral vascular action of bradykinin by the ‘bradykinin potentiating factor’ (BPF) in the dog

Zusammenfassung Die gefässerweiternde Wirkung von Bradykinin und Kallidin auf den cerebralen Kreislauf wurde durch den «BPF»-Faktor aus Schlangengift erheblich potenziert, während sie bei Eledoisin und Histamin nur wenig verändert wurde.     

老将重返战场

即使你不是汽车产业工作者,72岁的通用车厂的副总裁 Robert A.Lutz 也绝对是个值得你敬重的硬汉!这位纵横车坛超过40年、设计出无数经典车型的设计师早已到了含饴弄孙的年纪,但他还是接下了通用集团未来产品开发的重任,计划带领通用走出谷底,继续稳坐“世界第一”的宝座,我们来看看 Lutz 的过去(成名作)、现在和未来计划     

Cerebral vascular action of bradykinin in the dog

Zusammenfassung Die Wirkung von natürlichem und synthetischem Bradykinin auf den cerebralen Kreislauf wurde beim Hund in Chloralosenarkose durch die Registrierung des intracraniellen Venendruckes und Blutausflusses und des Nasenhöhlenplethysmogrammes untersucht. Bradykinin erzeugt in Dosen von 0.5–3 µg/kg i.v. eine deutliche Erweiterung der Hirngefässe, analog der durch eine gleiche oder etwas niedrigere Menge von Histamin hervorgerufenen. Im Gegensatz zum Histamin übt Bradykinin in dieser Dosierung keine erweiternde Wirkung auf die Nasenhöhlengefässe aus. Die durch Bradykinin erzeugte Zunahme der Gehirndurchblutung wird durch Neoantergan oder Atropin nicht gehemmt.     

A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains.

Cell polarization requires that a cellular axis or cell-surface site be chosen and that the cytoskeleton be organized with respect to it. Details of the link between the cytoskeleton and the chosen axis or site are not clear. Cells of the yeast Saccharomyces cerevisiae exhibit cell polarization in two phases of their life cycle, during vegetative growth and during mating, which reflects responses to intracellular and extracellular signals, respectively. Here we describe the isolation of two mutants defective specifically in cell polarization in response to peptide mating pheromones. The mutants carry special alleles (denoted bem1-s) of the BEM1 gene required for cell polarization during vegetative growth. Unlike other bem1 mutants, the bem1-s mutants are normal for vegetative growth. Complete deletion of BEM1 leads to the defect in polarization of vegetative cells seen in bem1 mutants. The predicted sequence of the BEM1 protein (Bem1p) reveals two copies of a domain (denoted SH3) that is found in many proteins associated with the cortical cytoskeleton and which may mediate binding to actin or some other component of the cell cortex. The sequence of Bem1p and the properties of mutants defective in this protein indicate that it may link the cytoskeleton to morphogenetic determinants on the cell surface.     

Reducing uncertainty in short-term projections: Linkage of monthly and quarterly models

This paper shows how monthly data and forecasts can be used in a systematic way to improve the predictive accuracy of a quarterly macroeconometric model. The problem is formulated as a model pooling procedure (equivalent to non-recursive Kalman filtering) where a baseline quarterly model forecast is modified through ‘add-factors’ or ‘constant adjustments’. The procedure ‘automatically’ constructs these adjustments in a covariance-minimizing fashion to reflect the revised expectation of the quarterly model's forecast errors, conditional on the monthly information set. Results obtained using Federal Reserve Board models indicate the potential for significant reduction in forecast error variance through application of these procedures.     

洞烛先机 2005年全球车坛9大趋势

光阴似箭,2004年转眼之间结束。过去12个月以来,全球车坛的风向标有了不少改变。什么是 CUV?小型车又开始当道?过去两年以来全球成长最快的是什么车型?你的下一辆车要选择柴油还是“混合动力”发动机?现在,我们要告诉你今年全球车坛的流行趋势摘要1 高油价时代来临,替代燃料车型愈来愈多摘要2 汽车用途多元化,小而美成为趋势     

A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures

We report a recurrent microdeletion syndrome causing mental retardation, epilepsy and variable facial and digital dysmorphisms. We describe nine affected individuals, including six probands: two with de novo deletions, two who inherited the deletion from an affected parent and two with unknown inheritance. The proximal breakpoint of the largest deletion is contiguous with breakpoint 3 (BP3) of the Prader-Willi and Angelman syndrome region, extending 3.95 Mb distally to BP5. A smaller 1.5-Mb deletion has a proximal breakpoint within the larger deletion (BP4) and shares the same distal BP5. This recurrent 1.5-Mb deletion contains six genes, including a candidate gene for epilepsy (CHRNA7) that is probably responsible for the observed seizure phenotype. The BP4-BP5 region undergoes frequent inversion, suggesting a possible link between this inversion polymorphism and recurrent deletion. The frequency of these microdeletions in mental retardation cases is approximately 0.3% (6/2,082 tested), a prevalence comparable to that of Williams, Angelman and Prader-Willi syndromes.