Purification of 2 succinic semi-aldehyde reductases from the human brain]

Two succinic semi-aldehyde reductases (A and B) have been purified to electrophoretic homogeneity. Enzyme A, which is a monomer of molecular weight 40,000 +/- 5,000 reduces a wide range of aldehydes and is inhibited by some barbiturates and certain anticonvulsants. Enzyme B, which is a dimer of molecular weight 80,000 +/- 10,000, is very specific for succinic semi-aldehyde and is not inhibited by the aforementioned compounds.     

Laboratory detection of X-ray fringes with a grazing-incidence interferometer

Starting with Galileo's observations of the Solar System, improvements of an order of magnitude in either the sensitivity or resolution of astronomical instruments have always brought revolutionary discoveries. The X-ray band of the spectrum, where exotic objects can have extremely high surface brightness, is ideally suited for significant improvements in imaging, but progress has been impeded by a lack of optics of sufficiently high sensitivity and quality. Here we present an X-ray interferometer design that is practical for adaptation to astronomical observatories. Our prototype interferometer, having just under one millimetre of baseline, creates fringes at 1.25 keV with an angular resolution of 100 milliarcseconds. With a larger version in orbit it will be possible to resolve X-ray sources at 10(-7) arcseconds, three orders of magnitude better than the finest-resolution images ever achieved on the sky (in the radio part of the spectrum) and over one million times better than the current best X-ray images. With such resolutions, we can study the environments of pulsars, resolve and then model relativistic blast waves, image material falling into a black hole, watch the physical formation of astrophysical jets, and study the dynamos of stellar coronae.     

Reach and grasp by people with tetraplegia using a neurally controlled robotic arm

Paralysis following spinal cord injury, brainstem stroke, amyotrophic lateral sclerosis and other disorders can disconnect the brain from the body, eliminating the ability to perform volitional movements. A neural interface system could restore mobility and independence for people with paralysis by translating neuronal activity directly into control signals for assistive devices. We have previously shown that people with long-standing tetraplegia can use a neural interface system to move and click a computer cursor and to control physical devices. Able-bodied monkeys have used a neural interface system to control a robotic arm, but it is unknown whether people with profound upper extremity paralysis or limb loss could use cortical neuronal ensemble signals to direct useful arm actions. Here we demonstrate the ability of two people with long-standing tetraplegia to use neural interface system-based control of a robotic arm to perform three-dimensional reach and grasp movements. Participants controlled the arm and hand over a broad space without explicit training, using signals decoded from a small, local population of motor cortex (MI) neurons recorded from a 96-channel microelectrode array. One of the study participants, implanted with the sensor 5?years earlier, also used a robotic arm to drink coffee from a bottle. Although robotic reach and grasp actions were not as fast or accurate as those of an able-bodied person, our results demonstrate the feasibility for people with tetraplegia, years after injury to the central nervous system, to recreate useful multidimensional control of complex devices directly from a small sample of neural signals.     

Detection of Earth-like planets around nearby stars using a petal-shaped occulter

Direct observation of Earth-like planets is extremely challenging, because their parent stars are about 10(10) times brighter but lie just a fraction of an arcsecond away. In space, the twinkle of the atmosphere that would smear out the light is gone, but the problems of light scatter and diffraction in telescopes remain. The two proposed solutions--a coronagraph internal to a telescope and nulling interferometry from formation-flying telescopes--both require exceedingly clean wavefront control in the optics. An attractive variation to the coronagraph is to place an occulting shield outside the telescope, blocking the starlight before it even enters the optical path. Diffraction and scatter around or through the occulter, however, have limited effective suppression in practically sized missions. Here I report an occulter design that would achieve the required suppression and can be built with existing technology. The compact mission architecture of a coronagraph is traded for the inconvenience of two spacecraft, but the daunting optics challenges are replaced with a simple deployable sheet 30 to 50 m in diameter. When such an occulter is flown in formation with a telescope of at least one metre aperture, terrestrial planets could be seen and studied around stars to a distance of ten parsecs.