排序方式: 共有7条查询结果,搜索用时 15 毫秒
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Crystal structure of TFIID TATA-box binding protein. 总被引:48,自引:0,他引:48
D B Nikolov S H Hu J Lin A Gasch A Hoffmann M Horikoshi N H Chua R G Roeder S K Burley 《Nature》1992,360(6399):40-46
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Structural genomics: beyond the human genome project. 总被引:17,自引:0,他引:17
S K Burley S C Almo J B Bonanno M Capel M R Chance T Gaasterland D Lin A Sali F W Studier S Swaminathan 《Nature genetics》1999,23(2):151-157
With access to whole genome sequences for various organisms and imminent completion of the Human Genome Project, the entire process of discovery in molecular and cellular biology is poised to change. Massively parallel measurement strategies promise to revolutionize how we study and ultimately understand the complex biochemical circuitry responsible for controlling normal development, physiologic homeostasis and disease processes. This information explosion is also providing the foundation for an important new initiative in structural biology. We are about to embark on a program of high-throughput X-ray crystallography aimed at developing a comprehensive mechanistic understanding of normal and abnormal human and microbial physiology at the molecular level. We present the rationale for creation of a structural genomics initiative, recount the efforts of ongoing structural genomics pilot studies, and detail the lofty goals, technical challenges and pitfalls facing structural biologists. 相似文献
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Résumé La densité du bois et la longueur de la fibre ont été l'objet de recherches dans 8 espèces d'Eucalyptus de Zambie. Les espèces diffèrent considérablement par leur densité (0.487–0.614 g/cm3), mais non par la longueur de leurs fibres (0.84–0.93 mm). 相似文献
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Recognizing DNA in the library 总被引:1,自引:0,他引:1
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Abbot P Abe J Alcock J Alizon S Alpedrinha JA Andersson M Andre JB van Baalen M Balloux F Balshine S Barton N Beukeboom LW Biernaskie JM Bilde T Borgia G Breed M Brown S Bshary R Buckling A Burley NT Burton-Chellew MN Cant MA Chapuisat M Charnov EL Clutton-Brock T Cockburn A Cole BJ Colegrave N Cosmides L Couzin ID Coyne JA Creel S Crespi B Curry RL Dall SR Day T Dickinson JL Dugatkin LA El Mouden C Emlen ST Evans J Ferriere R Field J Foitzik S Foster K Foster WA Fox CW Gadau J Gandon S 《Nature》2011,471(7339):E1-4; author reply E9-10
Arising from M. A. Nowak, C. E. Tarnita & E. O. Wilson 466, 1057-1062 (2010); Nowak et al. reply. Nowak et al. argue that inclusive fitness theory has been of little value in explaining the natural world, and that it has led to negligible progress in explaining the evolution of eusociality. However, we believe that their arguments are based upon a misunderstanding of evolutionary theory and a misrepresentation of the empirical literature. We will focus our comments on three general issues. 相似文献
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