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DNA methylation profiling of human chromosomes 6, 20 and 22 总被引:24,自引:0,他引:24
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Species-specific cell adhesion in marine sponges is mediated by a new family of modular proteoglycans whose general supramolecular
structure resembles that of hyalectans. However, neither their protein nor their glycan moieties have significant sequence
homology to other proteoglycans, despite having protein subunits equivalent to link proteins and to proteoglycan monomer core
proteins, and glycan subunits equivalent to hyaluronan and to the glycosaminoglycans of hyalectans. In some species, these
molecular components are assembled into a structure with a circular core formed by the link protein- and hyaluronan-like subunits.
Besides their involvement in cell adhesion, these sponge proteoglycans, for which we propose the term spongicans, participate
in signal transduction processes and are suspected to play a role in sponge self-nonself recognition. Their in vivo roles
and the mild methods used to purify large amounts of functionally active spongicans make them ideal models to study the functions
and possible new applications of proteoglycans in biomedical research.
Received 21 May 2002; received after revision 5 July 2002; accepted 10 July 2002
RID="*"
ID="*"Corresponding author. 相似文献
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Résumé L'injection de sérums provenant de différentes souches de souris, ainsi que de rats, de hamsters et de lapins, respectivement traités au Rivanol, de même que l'injection d'endotoxine bactérienne à des souris de souche C57Bl a pour effet d'augmenter la concentration d'haptoglobine dans le sérum de ces dernières. La fraction purifiée de 7S-globulines sériques humaines réduit cet effet. 相似文献
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Summary The factors involved in the regulation of biological membrane fusion and models proposed for the molecular mechanism of biomembrane fusion are reviewed. The results obtained in model systems are critically discussed in the light of the known properties of biomembranes and characteristics of biomembrane fusion. Biological membrane fusion is a local-point event; extremely fast, non-leaky, and under strict control. Fusion follows on a local and most probably protein-modulated destabilization, and a transition of the interacting membranes from a bilayer to a non-bilayer lipid structure. The potential role of type II non-bilayer preferring lipids and of proteins in the local destabilization of the membranes is evaluated. Proteins are not only responsible for the mutual recognition of the fusion partners, but are most likely also to be involved in the initiation of biomembrane fusion, by locally producing or activating fusogens, or by acting as fusogens. 相似文献
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We propose a localized address autoconfiguration (LaConf) scheme for wireless ad hoc networks.Address allocation information is maintained on the network border nodes,called addressing agents (AAs),which are locally identified by a geographic routing protocol GFG (Greedy-FACE-Greedy).When a node joins the network,it acquires an address from a neighboring AA (if any exists) by local communication or from the head AA (a geographic extreme AA) by GFG-based multi-hop communication.A Geographic Hash Table (GHT) ... 相似文献
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Steffens S Veillard NR Arnaud C Pelli G Burger F Staub C Karsak M Zimmer A Frossard JL Mach F 《Nature》2005,434(7034):782-786
Atherosclerosis is a chronic inflammatory disease, and is the primary cause of heart disease and stroke in Western countries. Derivatives of cannabinoids such as delta-9-tetrahydrocannabinol (THC) modulate immune functions and therefore have potential for the treatment of inflammatory diseases. We investigated the effects of THC in a murine model of established atherosclerosis. Oral administration of THC (1 mg kg(-1) per day) resulted in significant inhibition of disease progression. This effective dose is lower than the dose usually associated with psychotropic effects of THC. Furthermore, we detected the CB2 receptor (the main cannabinoid receptor expressed on immune cells) in both human and mouse atherosclerotic plaques. Lymphoid cells isolated from THC-treated mice showed diminished proliferation capacity and decreased interferon-gamma secretion. Macrophage chemotaxis, which is a crucial step for the development of atherosclerosis, was also inhibited in vitro by THC. All these effects were completely blocked by a specific CB2 receptor antagonist. Our data demonstrate that oral treatment with a low dose of THC inhibits atherosclerosis progression in the apolipoprotein E knockout mouse model, through pleiotropic immunomodulatory effects on lymphoid and myeloid cells. Thus, THC or cannabinoids with activity at the CB2 receptor may be valuable targets for treating atherosclerosis. 相似文献
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alpha-Actinin attached to membranes of secretory vesicles 总被引:8,自引:0,他引:8
B M Jockusch M M Burger M DaPrada J G Richards C Chaponnier G Gabbiani 《Nature》1977,270(5638):628-629
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