Appearance of growth-inhibiting activity (G1 chalone) during ontogenetic development of rat and chick epidermis in vivo and in vitro.

A comparative study was carried out between the stage of embryonic development of epidermis and its content of growth-inhibitory activity (G1 chalone). Injections of aqueous extracts from keratinized fetal rat or chick embryo epidermis led to a depression of DNA-synthesis in adult mouse epidermis, whereas extracts from undifferentiated epidermis did not contain such an activity.     

Discovery of a new population of high-energy gamma-ray sources in the Milky Way

One of the great mysteries of the high-energy gamma-ray sky is the group of approximately 170 unidentified point sources found along the Galactic plane. They are more numerous than all other high-energy gamma-ray sources combined and, despite 20 years of effort, no clear counterparts have been found at other wavelengths. Here we report a new population of such objects. A cluster of approximately 20 faint sources appears north of the Galactic Centre, which is part of a broader class of faint objects at mid-latitudes. In addition, we show in a model-independent way that the mid-latitude sources are distinct from the population of bright unidentified sources along the Galactic plane. The distribution on the sky indicates that the faint mid-latitude sources are associated with the Gould belt of massive stars and gas clouds at approximately 600 light years distance, as has been previously suggested.     

Appearance of growth-inhibiting activity (G1 chalone) during ontogenetic development of rat and chick epidermis in vivo and in vitro

Summary A comparative study was carried out between the stage of embryonic development of epidermis and its content of growth-inhibitory activity (G₁ chalone). Injections of aqueous extracts from keratinized fetal rat or chick embryo epidermis led to a depression of DNA-synthesis in adult mouse epidermis, whereas extracts from undifferentiated epidermis did not contain such an activity.This investigation was supported by the Deutsche Forschungsgemeinschaft.