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Summary Apomorphine was administered parenterally to mice in an unsuccessful attempt to induce amphetamine and L-3,4-dihydroxyphenylalanine-like elicited jumping. The efficacy of jumping behavior as an indicator of dopaminergic overstimulation is criticized in light of the results. 相似文献
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Apomorphine was administered parenterally to mice in an unsuccessful attempt to induce amphetamine and L-3,4-dihydroxyphenylalanine-like elicited jumping. The efficacy of jumping behavior as an indicator of dopaminergic overstimulation is criticized in light of the results. 相似文献
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Elefteriou F Ahn JD Takeda S Starbuck M Yang X Liu X Kondo H Richards WG Bannon TW Noda M Clement K Vaisse C Karsenty G 《Nature》2005,434(7032):514-520
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Role of endogenous substance P in stress-induced activation of mesocortical dopamine neurones 总被引:1,自引:0,他引:1
The dopamine (DA) innervation to the forebrain arises from subpopulations of midbrain DA neurones broadly classified as nigrostriatal, mesolimbic and mesocortical. Significant differences in the autoregulatory mechanisms and neuronal inputs of these DA pathways may account for their differences in physiological and pharmacological responsiveness. For example, footshock stress can activate rat mesocortical DA cells but does not alter nigrostriatal DA turnover, while also decreasing substance P (SP) concentrations in the midbrain interpeduncular nucleus and in the adjacent ventral tegmental area (VTA), but not in the substantia nigra (SN). This suggested that the activation of the SP input to the VTA may mediate activation of certain DA systems by footshock stress; behavioural studies also had suggested an excitatory effect of SP on DA cells in the VTA. SP antagonists now available are neurotoxic and of questionable efficacy, we therefore used monoclonal antibody against SP. Antibody microinjected into the VTA prevented normal footshock-induced activation of mesocortical DA neurones, suggesting mediation by SP input to the VTA. The in vivo application of antibodies may prove valuable in studies of neuropeptides in the central nervous system (CNS). 相似文献
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