脑血管药理学与中药新药研究

目的:探讨脑血管药理学研究的必要性,及其中药在此方面的可能的优势.方法:通过对文献分析和我们研究体会,对此进行探讨.结果与结论:随着脑血管病发病率的日渐升高,对该类疾病的进行专门研究也为学术界所重视.脑血管病由于其解剖和病生理学独特性而不完全同于心血管病和神经系统疾病,它既具有心血管病的一般特性,又更具复杂性.目前针对性较强的脑血管疾病的药物不多,很大程度上与脑血管药理学研究的进展程度有关.药以其多成分多靶点作用的特点,将在脑血管病治疗扮演重要角色.     

基于稀疏表示算法的气体绝缘组合电器(GIS)局部放电识别

为提高GIS绝缘缺陷的识别正确率,针对GIS出现的绝缘缺陷以及产生的局部放电特点,设计了4种典型绝缘缺陷物理模型,对获得的局部放电灰度图谱,用稀疏表示分类算法进行缺陷类型识别。该算法首先用最小——范数方法计算稀疏表示系数,运用压缩感知将低维观测信号恢复到高维原始信号。通过计算各类缺陷局部放电灰度图的最小残差来进行图像匹配,避开了一般模式识别分类算法中较为复杂的特征提取。测试结果表明该方法对GIS各类模拟缺陷的正确识别率较高。     

Cerebral Ischemia Reperfusion Exacerbates and Pueraria Flavonoids Attenuate Depressive Responses to Stress in Mice

Previous studies have shown that mice experiencing cerebral ischemia reperfusion （CIR） and stress can serve as a model of post stroke depression （PSD）. The present study verified the acute antidepressant effects of radix puerariae extract （PE） on PSD mice through behavior and gene expression experiments. CIR was found to reduce the sucrose consumption and tyrosine hydroxylase （TH） gene expression. PE administration after CIR surgery was observed to significantly enhance the mRNA expression of TH in the hippocampus compared with the PSD group on Day 0 and Day 3 postsurgery. These findings indicate that PE contributes to the amelioration of behavior response in PSD mice, which is closely related with the protective effects of catecholamine synthesize against CIR brain damage.