Conformational Changes in HL60 Cells during Differentiation and Apoptosis Induced by Genistein

IntroductionGenistein is a naturally occurring phytoestrogenpresent in a variety of plant foods,includingsoybean[1] .It is known to inhibit both tyrosineprotein kinases and DNA topoisomerase II.Akiyama et al.[2 ] described the ability of genisteinto specifically inhibit protein tyrosine kinase( PTKs) ,presumably at the level of the ATPbinding site.PTKs seem to play a key role intumorigenesis and are known to be associated withgrowth control receptors such as epidermal growthfactors[3] ,p…     

Effects of Dioscin Extracted from Polygonatum Zanlanscianense Pamp on Several Human Tumor Cell Lines

IntroductionPolygonatum Zanlanscianense Pamp grows insoutheastern Gansu and southwestern Shaanxi,China.Its roots are used as a substitute for“Yuzhu”,a famous traditional Chinese medicinethat has long been used in the treatment of lungillnesses,palpitation,upset stomach anddiabetes[12 ] .A literature survey showed thatseveral Polygonatum species have already beenchemically studied and found to contain steroidalsaponins[3 5] .However,there are no reports on thechemical properties of Polygo…