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A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. 总被引:46,自引:0,他引:46
P Basset J P Bellocq C Wolf I Stoll P Hutin J M Limacher O L Podhajcer M P Chenard M C Rio P Chambon 《Nature》1990,348(6303):699-704
A gene has been identified that is expressed specifically in stromal cells surrounding invasive breast carcinomas. On the basis of its sequence, the product of this gene, named stromelysin-3, is a new member of the family of metalloproteinase enzymes which degrade the extracellular matrix. The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies. 相似文献
3.
Byrne JA Pedersen DA Clepper LL Nelson M Sanger WG Gokhale S Wolf DP Mitalipov SM 《Nature》2007,450(7169):497-502
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Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus 总被引:1,自引:0,他引:1
Zhu L Vranckx R Khau Van Kien P Lalande A Boisset N Mathieu F Wegman M Glancy L Gasc JM Brunotte F Bruneval P Wolf JE Michel JB Jeunemaitre X 《Nature genetics》2006,38(3):343-349
We have recently described two kindreds presenting thoracic aortic aneurysm and/or aortic dissection (TAAD) and patent ductus arteriosus (PDA) and mapped the disease locus to 16p12.2-p13.13 (ref. 3). We now demonstrate that the disease is caused by mutations in the MYH11 gene affecting the C-terminal coiled-coil region of the smooth muscle myosin heavy chain, a specific contractile protein of smooth muscle cells (SMC). All individuals bearing the heterozygous mutations, even if asymptomatic, showed marked aortic stiffness. Examination of pathological aortas showed large areas of medial degeneration with very low SMC content. Abnormal immunological recognition of SM-MHC and the colocalization of wild-type and mutant rod proteins in SMC, in conjunction with differences in their coimmunoprecipitation capacities, strongly suggest a dominant-negative effect. Human MYH11 gene mutations provide the first example of a direct change in a specific SMC protein leading to an inherited arterial disease. 相似文献
6.
At the end of mitosis, daughter cells are separated from each other by cytokinesis. This process involves equal partitioning
and segregation of cytoplasm between the two cells. Despite years of study, the mechanism driving cytokinesis in animal cells
is not fully understood. Actin and myosin are major components of the contractile ring, the structure at the equator between
the dividing cells that provides the force necessary to constrict the cytoplasm. Despite this, there are also tantalizing
results suggesting that cytokinesis can occur in the absence of myosin. It is unclear what the roles are of the few other
contractile ring components identified to date. While it has been difficult to identify important proteins involved in cytokinesis,
it has been even more challenging to pinpoint the regulatory mechanisms that govern this vital process. Cytokinesis must be
precisely controlled both spatially and temporally; potential regulators of these parameters are just beginning to be identified.
This review discusses the recent progress in our understanding of cytokinesis in animal cells and the mechanisms that may
regulate it.
Received 24 August 1998; received after revision 9 October 1998; accepted 9 October 1998 相似文献
7.
Zusammenfassung Es wird gezeigt, dass Knochenentwicklung junger Ratten durch Behandlung mit Polyethylen-Polyphosphonat ohne toxische Wirkung verhindert wird. Die Polyphosphonate wirken direkt auf den Knochen und können eventuell verschiedene klinische Anwendungen finden.
Supported by Public Health Grant No. GM 17367-01. 相似文献
Supported by Public Health Grant No. GM 17367-01. 相似文献
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N. Radoiu F. A. Zydeck E. T. Konno P. L. Wolf 《Cellular and molecular life sciences : CMLS》1968,24(11):1170-1171
Zusammenfassung Durch ein immunologisches Dreieck-System (Hund-Kaninchen-Hund) wurde ein Anti-Antikörper bei Hunden erzeugt und seine Wirkung in vitro und in vivo demonstriert. Die Anti-Antikörper-Methode bietet neue Möglichkeiten, dem Problem der Transplantat-Abstossung und der Therapie der Krankheiten immunologischen Ursprungs näherzukommen.
This investigation was supported by Public Health Service grant No. CA 02624 and the Detroit General Hospital Research Corp. and Metropolitan Hospital Research grant NO. 208-12. 相似文献
This investigation was supported by Public Health Service grant No. CA 02624 and the Detroit General Hospital Research Corp. and Metropolitan Hospital Research grant NO. 208-12. 相似文献
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