爱因斯坦A-Z

本书是一本传记性著作，记述了20世纪最伟大的科学家之一爱因斯坦的生平。与其他传记体文学不同的是，本书别出心裁的以字母表的顺序，以关键词的方式记录了爱因斯坦的生活、科研、理想等等。从第一个单词大大咧咧的（Absentmindeness），一直到最后一个单词犹太复国主义（Zionism）。每个单词作为一章的标题引出了一段或惊险、或平淡的故事。从本书中读者可以了解爱因斯坦在科学方面的天才想法，可以读到他作为普通人生活的一面——一个可怜的丈夫和父亲，还有他在核武器方面的影响，他创造了相对论却拒绝接受量子力学……     

Structural diversity and African origin of the 17q21.31 inversion polymorphism

The 17q21.31 inversion polymorphism exists either as direct (H1) or inverted (H2) haplotypes with differential predispositions to disease and selection. We investigated its genetic diversity in 2,700 individuals, with an emphasis on African populations. We characterize eight structural haplotypes due to complex rearrangements that vary in size from 1.08-1.49 Mb and provide evidence for a 30-kb H1-H2 double recombination event. We show that recurrent partial duplications of the KANSL1 gene have occurred on both the H1 and H2 haplotypes and have risen to high frequency in European populations. We identify a likely ancestral H2 haplotype (H2') lacking these duplications that is enriched among African hunter-gatherer groups yet essentially absent from West African populations. Whereas H1 and H2 segmental duplications arose independently and before human migration out of Africa, they have reached high frequencies recently among Europeans, either because of extraordinary genetic drift or selective sweeps.