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Life cycle of Tripedalia cystophora Conant (Cubomedusae) 总被引:5,自引:0,他引:5
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Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots 总被引:19,自引:0,他引:19
Phillips MS Lawrence R Sachidanandam R Morris AP Balding DJ Donaldson MA Studebaker JF Ankener WM Alfisi SV Kuo FS Camisa AL Pazorov V Scott KE Carey BJ Faith J Katari G Bhatti HA Cyr JM Derohannessian V Elosua C Forman AM Grecco NM Hock CR Kuebler JM Lathrop JA Mockler MA Nachtman EP Restine SL Varde SA Hozza MJ Gelfand CA Broxholme J Abecasis GR Boyce-Jacino MT Cardon LR 《Nature genetics》2003,33(3):382-387
Recent studies of human populations suggest that the genome consists of chromosome segments that are ancestrally conserved ('haplotype blocks'; refs. 1-3) and have discrete boundaries defined by recombination hot spots. Using publicly available genetic markers, we have constructed a first-generation haplotype map of chromosome 19. As expected for this marker density, approximately one-third of the chromosome is encompassed within haplotype blocks. Evolutionary modeling of the data indicates that recombination hot spots are not required to explain most of the observed blocks, providing that marker ascertainment and the observed marker spacing are considered. In contrast, several long blocks are inconsistent with our evolutionary models, and different mechanisms could explain their origins. 相似文献
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