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Steffen Ducheyne 《Studies in history and philosophy of science》2005,36(1):61-78
In this paper I deal with a neglected topic with respect to unification in Newton’s Principia. I will clarify Newton’s notion (as can be found in Newton’s utterances on unification) and practice of unification (its actual occurrence in his scientific work). In order to do so, I will use the recent theories on unification as tools of analysis (Kitcher, Salmon and Schurz). I will argue, after showing that neither Kitcher’s nor Schurz’s account aptly capture Newton’s notion and practice of unification, that Salmon’s later work is a good starting point for analysing this notion and its practice in the Principia. Finally, I will supplement Salmon’s account in order to answer the question at stake. 相似文献
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Learning causes a change in how information is processed by neuronal circuits. Whereas synaptic plasticity, an important cellular mechanism, has been studied in great detail, we know much less about how learning is implemented at the level of neuronal circuits and, in particular, how interactions between distinct types of neurons within local networks contribute to the process of learning. Here we show that acquisition of associative fear memories depends on the recruitment of a disinhibitory microcircuit in the mouse auditory cortex. Fear-conditioning-associated disinhibition in auditory cortex is driven by foot-shock-mediated cholinergic activation of layer 1 interneurons, in turn generating inhibition of layer 2/3 parvalbumin-positive interneurons. Importantly, pharmacological or optogenetic block of pyramidal neuron disinhibition abolishes fear learning. Together, these data demonstrate that stimulus convergence in the auditory cortex is necessary for associative fear learning to complex tones, define the circuit elements mediating this convergence and suggest that layer-1-mediated disinhibition is an important mechanism underlying learning and information processing in neocortical circuits. 相似文献
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Hüffmeier U Uebe S Ekici AB Bowes J Giardina E Korendowych E Juneblad K Apel M McManus R Ho P Bruce IN Ryan AW Behrens F Lascorz J Böhm B Traupe H Lohmann J Gieger C Wichmann HE Herold C Steffens M Klareskog L Wienker TF Fitzgerald O Alenius GM McHugh NJ Novelli G Burkhardt H Barton A Reis A 《Nature genetics》2010,42(11):996-999
Psoriatic arthritis (PsA) is an inflammatory joint disease that is distinct from other chronic arthritides and which is frequently accompanied by psoriasis vulgaris (PsV) and seronegativity for rheumatoid factor. We conducted a genome-wide association study in 609 German individuals with PsA (cases) and 990 controls with replication in 6 European cohorts including a total of 5,488 individuals. We replicated PsA associations at HLA-C and IL12B and identified a new association at TRAF3IP2 (rs13190932, P = 8.56 × 10?1?). TRAF3IP2 was also associated with PsV in a German cohort including 2,040 individuals (rs13190932, P = 1.95 × 10?3). Sequencing of the exons of TRAF3IP2 identified a coding variant (p.Asp10Asn, rs33980500) as the most significantly associated SNP (P = 1.13 × 10?2?, odds ratio = 1.95). Functional assays showed reduced binding of this TRAF3IP2 variant to TRAF6, suggesting altered modulation of immunoregulatory signals through altered TRAF interactions as a new and shared pathway for PsA and PsV. 相似文献
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Different shades of Newton: Herman Boerhaave on Newton mathematicus,philosophus, and optico-chemicus
Steffen Ducheyne 《Annals of science》2013,70(2):108-125
In this paper I will probe into Herman Boerhaave's (1668–1738) appropriation of Isaac Newton's natural philosophy. It will be shown that Newton's work served multiple purposes in Boerhaave's oeuvre, for he appropriated Newton's work differently in different contexts and in different episodes in his career. Three important episodes in, and contexts of, Boerhaave's appropriation of Newton's natural philosophical ideas and methods will be considered: 1710–11, the time of his often neglected lectures on the place of physics in medicine; 1715, when he delivered his most famous rectorial address; and, finally, 1731/2, in publishing his Elementa chemiae. Along the way, I will spell out the implications of Boerhaave's case for our understanding of the reception, or use, of Newton's ideas more generally. 相似文献
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Kalscheuer VM Freude K Musante L Jensen LR Yntema HG Gécz J Sefiani A Hoffmann K Moser B Haas S Gurok U Haesler S Aranda B Nshedjan A Tzschach A Hartmann N Roloff TC Shoichet S Hagens O Tao J Van Bokhoven H Turner G Chelly J Moraine C Fryns JP Nuber U Hoeltzenbein M Scharff C Scherthan H Lenzner S Hamel BC Schweiger S Ropers HH 《Nature genetics》2003,35(4):313-315
We found mutations in the gene PQBP1 in 5 of 29 families with nonsyndromic (MRX) and syndromic (MRXS) forms of X-linked mental retardation (XLMR). Clinical features in affected males include mental retardation, microcephaly, short stature, spastic paraplegia and midline defects. PQBP1 has previously been implicated in the pathogenesis of polyglutamine expansion diseases. Our findings link this gene to XLMR and shed more light on the pathogenesis of this common disorder. 相似文献
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The high mechanical and thermal performance of poly p-phenylene- 2, 6-benzobisoxazole ( PBO ) fiber provides great potential applications as reinforcement fibers for composites. A composite of PBO fiber and epoxy resin has excellent electrical insulation properties, therefore, it is considered to be the best choice for the reinforcement in high magnetic field coils for pulsed magnetic fields up to 100 T.However, poor adhesion between PBO fiber and matrix is found because of the chemically inactive and/or relatively smooth surface of the reinforcement fiber preventing efficient chemical bonding in the interface, which is a challenging issue to improve mechanical properties. Here, we report the surface modification of PBO fibers by ultraviolet (UV)irradiation, O2 and NH3 plasma, as well as acidic treatments. The interfacial adhesion strength values of all the treatments show the similar level as determined for aramid fibers by pull-out tests, a significant impact on fibermatrix-adhesion was not achieved. The surface free energy and roughness are increased for both sized and extracted fibers after plasma treatments together with maleic anhydride grafting. The sized fiber shows marginal improvement in adhesion strength and no change in fiber tensile strength because of the barrier effect of the finish.For the extracted fiber, different surface treatments either show no apparent effect or cause reduction in adhesion strength. Atomic force microscopy (AFM) topography analysis of the fracture surfaces proved adhesive failure at the fiber surface. The fiber surface roughness is increased and more surface flaws are induced, which could result in coarse interface structures when the treated fiber surface has no adequate wetting and functional groups. The adhesion failure is further confirmed by similar adhesion strength and compression shear strength values when the fiber was embedded in various epoxy resins with different temperature behavior. The tensile strength of fiber is sensitive to surface treatment conditions as revealed by a bimodal Weibull statistical distribution analysis. Considerable strength reduction occurred, particularly for cases of acidic and plasma treatments, while UV irradiation shows the better ability to retain fiber strength. 相似文献
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J. Merten A. Hennig P. Metz 《复旦学报(自然科学版)》2005,44(5):730-731
The highly oxygenated 1,10-seco-eudesmanolides ( - )-eriolanin ( 1 ) and ( - )-eriolangin (2) isolated from the plant Eriophyllum lanatum (Asteraceae) inhibit the growth of the human KB tumor cell line in vitro and additionally display a significant antileukemie activity in vivo in mice (Scheme 1 ). Using novel methods for the synthetic elaboration of sultones, the first enantioseleetive total syntheses of 1 and 2 have been accomplished, which also established the hitherto unknown absolute configuration of these natural produets. 相似文献
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Steffen Ducheyne 《Foundations of Science》2006,11(4):419-447
In this paper an analysis of Newton’s argument for universal gravitation is provided. In the past, the complexity of the argument
has not been fully appreciated. Recent authors like George E. Smith and William L. Harper have done a far better job. Nevertheless,
a thorough account of the argument is still lacking. Both authors seem to stress the importance of only one methodological
component. Smith stresses the procedure of approximative deductions backed-up by the laws of motion. Harper stresses “systematic
dependencies” between theoretical parameters and phenomena. I will argue that Newton used a variety of different inferential
strategies: causal parsimony considerations, deductions, demonstrative inductions, abductions and thought-experiments. Each
of these strategies is part of Newton’s famous argument. 相似文献