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Structure and conformation of a cyclic tripeptide 总被引:1,自引:0,他引:1
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Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac 总被引:15,自引:0,他引:15
Max M Shanker YG Huang L Rong M Liu Z Campagne F Weinstein H Damak S Margolskee RF 《Nature genetics》2001,28(1):58-63
The ability to taste the sweetness of carbohydrate-rich foodstuffs has a critical role in the nutritional status of humans. Although several components of bitter transduction pathways have been identified, the receptors and other sweet transduction elements remain unknown. The Sac locus in mouse, mapped to the distal end of chromosome 4 (refs. 7-9), is the major determinant of differences between sweet-sensitive and -insensitive strains of mice in their responsiveness to saccharin, sucrose and other sweeteners. To identify the human Sac locus, we searched for candidate genes within a region of approximately one million base pairs of the sequenced human genome syntenous to the region of Sac in mouse. From this search, we identified a likely candidate: T1R3, a previously unknown G protein-coupled receptor (GPCR) and the only GPCR in this region. Mouse Tas1r3 (encoding T1r3) maps to within 20,000 bp of the marker closest to Sac (ref. 9) and, like human TAS1R3, is expressed selectively in taste receptor cells. By comparing the sequence of Tas1r3 from several independently derived strains of mice, we identified a specific polymorphism that assorts between taster and non-taster strains. According to models of its structure, T1r3 from non-tasters is predicted to have an extra amino-terminal glycosylation site that, if used, would interfere with dimerization. 相似文献
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Harsha HC Suresh S Amanchy R Deshpande N Shanker K Yatish AJ Muthusamy B Vrushabendra BM Rashmi BP Chandrika KN Padma N Sharma S Badano JL Ramya MA Shivashankar HN Peri S Choudhury DR Kavitha MP Saravana R Niranjan V Gandhi TK Ghosh N Chandran S Menezes M Joy M Mohan SS Katsanis N Deshpande KS Raghothama C Prasad CK Pandey A 《Nature genetics》2005,37(4):331-332
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Siddiqui MR Meisner S Tosh K Balakrishnan K Ghei S Fisher SE Golding M Shanker Narayan NP Sitaraman T Sengupta U Pitchappan R Hill AV 《Nature genetics》2001,27(4):439-441
Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is prevalent in India, where about half of the world's estimated 800,000 cases occur. A role for the genetics of the host in variable susceptibility to leprosy has been indicated by familial clustering, twin studies, complex segregation analyses and human leukocyte antigen (HLA) association studies. We report here a genetic linkage scan of the genomes of 224 families from South India, containing 245 independent affected sibpairs with leprosy, mainly of the paucibacillary type. In a two-stage genome screen using 396 microsatellite markers, we found significant linkage (maximum lod score (MLS) = 4.09, P < 2x10-5) on chromosome 10p13 for a series of neighboring microsatellite markers, providing evidence for a major locus for this prevalent infectious disease. Thus, despite the polygenic nature of infectious disease susceptibility, some major, non-HLA-linked loci exist that may be mapped through obtainable numbers of affected sibling pairs. 相似文献
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