高电压十二相可逆电路的环流

讨论了高电压十二相可逆电路的环流问题 ,给出了环流波形图 ,并简要说明了波形图的使用方法 .所得结论可为工程技术人员设计系统提供方便 .     

公交IC卡收费系统与客流数据采集、处理

根据目前国内公交收费的发展趋势,设计出用于对客流等数据采集的IC卡自动收费系统,并提出利用它来进行客流等数据采集、处理的新方案.与人工调查相比,它的投入小得多,并且可以提供大量详细、准确的动态数据,对城市公交以及公交的智能化调度、线路的开辟、优化、站点的设置等都具有极其重要的意义.     

大体积覆土开挖卸载对盾构隧道的变形影响

采用有限元软件,对曹妃甸工业区跨纳潮河综合盾构隧道管廊在运营阶段上方规划河的开挖工况进行了分析,对大范围覆土卸载条件下的盾构隧道变形进行了研究．结果表明：盾构隧道在上方覆土开挖卸载时变形存在4处反弯点．通过加密设置变形缝,可满足盾构变形需要．     

When calcium goes wrong: genetic alterations of a ubiquitous signaling route

In all eukaryotic cells, the cytosolic concentration of calcium ions ([Ca2+]c) is tightly controlled by complex interactions among transporters, pumps, channels and binding proteins. Finely tuned changes in [Ca2+]c modulate a variety of intracellular functions, and disruption of Ca2+ handling leads to cell death. Here we review the human genetic diseases associated with perturbations in the Ca2+ signaling machinery. Despite the importance of Ca2+ in physiology and pathology, the number of known genetic diseases that can be attributed to defects in proteins directly involved in Ca2+ homeostasis is limited to few examples, which will be discussed. This paucity in contrast with the wide molecular repertoire may depend on the extreme severity of the phenotype (leading to death in utero) or, conversely, on functional compensation due to redundancy. In the latter case, it stands to reason that other genetic defects in calcium signaling have yet to be identified owing to their subtle phenotype.     

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

Mutations in leucine-rich repeat kinase 2 (LRRK2) are a major cause of familial Parkinsonism, and the G2019S mutation of LRRK2 is one of the most prevalent mutations. The deregulation of autophagic processes in nerve cells is thought to be a possible cause of Parkinson’s disease (PD). In this study, we observed that G2019S mutant fibroblasts exhibited higher autophagic activity levels than control fibroblasts. Elevated levels of autophagic activity can trigger cell death, and in our study, G2019S mutant cells exhibited increased apoptosis hallmarks compared to control cells. LRRK2 is able to induce the phosphorylation of MAPK/ERK kinases (MEK). The use of 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene (U0126), a highly selective inhibitor of MEK1/2, reduced the enhanced autophagy and sensibility observed in G2019S LRRK2 mutation cells. These data suggest that the G2019S mutation induces autophagy via MEK/ERK pathway and that the inhibition of this exacerbated autophagy reduces the sensitivity observed in G2019S mutant cells.     

二次冷却对板坯中间裂纹的影响

目前,如何在保证铸坯质量的前提下提高内部质量,特别是防止影响最终产品轧制性能的严重中间裂纹的出现,是转炉一连铸治金工艺路线存在地普遍问题。结合连铸板坯凝固过程的二冷DYNACS冷却模型模拟计算,阐述了二次冷却对铸坯中间裂纹的影响,并在此基础上提出了解决方案。     

计算机在人力资源管理系统中的应用

本文阐述了人力资源管理的基本概念及其发展动态，人力资源计算机管理系统设计中应考虑的几个主要方面，并运用ACCESS 2000、SQLSERVER 2000、JAVA，建立了人力资源计算机管理系统．该系统具有雇员管理、合同管理、考勤休假管理、绩效考核管理等方面的功能。     

SBR法生物后处理喹吖啶酮颜料中间体废水实验研究

采用SBR法处理喹吖啶酮颜料中间体废水,考察了SBR法处理喹吖啶酮颜料中间体废水的效果、曝气时间、pH值和进水COD值等条件对处理效果的影响。结果表明曝气时间6h、进水pH值为7.0~8.5、进水COD值为1000~2 000mg/L时,COD去除率达到71.3%~77.2%。     

灰色残差修正模型在中长期负荷预测中的应用

电力系统负荷预测是电力系统发电计划的重要组成部分,也是电力系统经济运行的基础。本文在应用GM（1,1）模型的基础上,建立了两种应用残差对预测数据进修正的模型。实例表明本文提出的方法较传统GM（1,1）模型有更高的精度。