随机模糊环境下企业动态生产计划编制

企业面对多变的内外部条件,处于动态、随机、模糊环境下。在这种环境下,企业如何决策自己的发展规划,制定合理的计划,并确保计划目标的实现,是一个关键的问题。应用多阶段决策理论,结合随机与模糊理论,构造了企业多阶段动态发展模型,建立了全状态转移矩阵,提出了随机熵权等概念,并对典型的动态发展与随机模糊企业系统--煤矿企业系统进行生产接续计划的编制,力争对多阶段决策理论和随机模糊理论的发展有所贡献。     

A recurrent mutation in PALB2 in Finnish cancer families

BRCA1, BRCA2 and other known susceptibility genes account for less than half of the detectable hereditary predisposition to breast cancer. Other relevant genes therefore remain to be discovered. Recently a new BRCA2-binding protein, PALB2, was identified. The BRCA2-PALB2 interaction is crucial for certain key BRCA2 DNA damage response functions as well as its tumour suppression activity. Here we show, by screening for PALB2 mutations in Finland that a frameshift mutation, c.1592delT, is present at significantly elevated frequency in familial breast cancer cases compared with ancestry-matched population controls. The truncated PALB2 protein caused by this mutation retained little BRCA2-binding capacity and was deficient in homologous recombination and crosslink repair. Further screening of c.1592delT in unselected breast cancer individuals revealed a roughly fourfold enrichment of this mutation in patients compared with controls. Most of the mutation-positive unselected cases had a familial pattern of disease development. In addition, one multigenerational prostate cancer family that segregated the c.1592delT truncation allele was observed. These results indicate that PALB2 is a breast cancer susceptibility gene that, in a suitably mutant form, may also contribute to familial prostate cancer development.     

The Entropies Evaluation of the High-entropy System and its Determination of Operating Entropy

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