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C. Biemont E. S. Belyaeva E. G. Pasyukova G. Kogan 《Cellular and molecular life sciences : CMLS》1985,41(11):1474-1476
Summary The location of the mobile element mdg-1 was determined by in situ hybridization in salivary gland chromosomes ofDrosophila melanogaster. The locations of mdg-1 are nonrandom and some hot spots exist. Moreover, the spectra of mdg-1 locations vary with the viability values of the families from which the larvae originated. This suggests that particular frequency spectra are associated with lethality resulting from inbreeding. 相似文献
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De Luca M Roshina NV Geiger-Thornsberry GL Lyman RF Pasyukova EG Mackay TF 《Nature genetics》2003,34(4):429-433
Mutational analyses in model organisms have shown that genes affecting metabolism and stress resistance regulate life span, but the genes responsible for variation in longevity in natural populations are largely unidentified. Previously, we mapped quantitative trait loci (QTLs) affecting variation in longevity between two Drosophila melanogaster strains. Here, we show that the longevity QTL in the 36E;38B cytogenetic interval on chromosome 2 contains multiple closely linked QTLs, including the Dopa decarboxylase (Ddc) locus. Complementation tests to mutations show that Ddc is a positional candidate gene for life span in these strains. Linkage disequilibrium (LD) mapping in a sample of 173 alleles from a single population shows that three common molecular polymorphisms in Ddc account for 15.5% of the genetic contribution to variance in life span from chromosome 2. The polymorphisms are in strong LD, and the effects of the haplotypes on longevity suggest that the polymorphisms are maintained by balancing selection. DDC catalyzes the final step in the synthesis of the neurotransmitters, dopamine and serotonin. Thus, these data implicate variation in the synthesis of bioamines as a factor contributing to natural variation in individual life span. 相似文献
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