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N. Davidson Edna I. Macfarlane Diane L. Michie 《Cellular and molecular life sciences : CMLS》1977,33(7):935-936
Summary The effects of 2 of a series of bicyclic phosphorous esters, the ethyl (EPTBO) and isopropyl (IPTBO) compounds, were compared with those of the GABA antagonists, picrotoxin and bicuculline, on presynaptic inhibition in the rat cuneate nucleus. Both EPTBO and IPTBO were found to be effective, reversible antagonists of presynaptic inhibition, with IPTBO approximately 10 times more potent than EPTBO and equipotent with bicuculline, EPTBO equipotent with picrotoxin.The authors are grateful to Dr J. F. Collins, Department of Chemistry, Sir John Cass School of Science and Technology, 31 Jewry Street, London, for the gift of bicyclic phosphorous esters. 相似文献
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Bailey Richard E. Bartos Dagmar Bartos F. Castro A. Dobson R. L. Grettie D. P. Kramer Rosanne Macfarlane Dorothy Sato K. 《Cellular and molecular life sciences : CMLS》1972,28(2):159-160
Résumé Un stress thermique aigu est un activateur rapide et puissant de la sécrétion du système rénineangiotensine et de l'aldosterone au cours d'une alimentation normo ou hyposodée, et peut être utilisé pour mesurer l'intégrité des systèmes de production de ces hormones. 相似文献
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S N Bose R J Davies D W Anderson J C Van Niekerk L R Nassimbeni R D Macfarlane 《Nature》1978,271(5647):783-784
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Hashibe M McKay JD Curado MP Oliveira JC Koifman S Koifman R Zaridze D Shangina O Wünsch-Filho V Eluf-Neto J Levi JE Matos E Lagiou P Lagiou A Benhamou S Bouchardy C Szeszenia-Dabrowska N Menezes A Dall'Agnol MM Merletti F Richiardi L Fernandez L Lence J Talamini R Barzan L Mates D Mates IN Kjaerheim K Macfarlane GJ Macfarlane TV Simonato L Canova C Holcátová I Agudo A Castellsagué X Lowry R Janout V Kollarova H Conway DI McKinney PA Znaor A Fabianova E Bencko V Lissowska J Chabrier A Hung RJ 《Nature genetics》2008,40(6):707-709
Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology. 相似文献
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