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A role for MLH3 in hereditary nonpolyposis colorectal cancer 总被引：10，自引：0，他引：10
Wu Y Berends MJ Sijmons RH Mensink RG Verlind E Kooi KA van der Sluis T Kempinga C van dDer Zee AG Hollema H Buys CH Kleibeuker JH Hofstra RM 《Nature genetics》2001,29(2):137-138
We investigated a possible role of the mismatch-repair gene MLH3 in hereditary nonpolyposis colorectal cancer by scanning for mutations in 39 HNPCC families and in 288 patients suspected of having HNPCC. We identified ten different germline MLH3 variants, one frameshift and nine missense mutations, in 12 patients suspected of HNPCC. Three of the 12 also carried a mutation in MSH6. 相似文献
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