Development of City Transport System and Two-wheel Vehicles

Based on the study on the city transport systems of some typical cities worldwide, this paper put forward that each city transport system has its own development mode, which is influenced by the city development plan, economic development level, traveling vehicle composition etc.. When some problems occur, such as the congestions caused by contradiction between the road capacity and vehicle composition, the city transport system may come into temporary maturity period. If the improvement for road system is limited meanwhile, optimized structure of vehicle composition should be an effective solution in this case. With the development of economy-internationalization, the development speed of city transport modernization is rapid. When traveling easiness is conflicting with efficiency, the advantages of public transport system become more obvious. Correspondingly, the superiority of two-wheel vehicles will reappear. Though the important function of two-wheel vehicles for alleviating city traffic problems i     

A novel fluorination reaction: The interaction of perchloryl fluoride with active methylene compounds

Zusammenfassung Die Reaktion von Perchloryl Fluorid (PF) mit Anionen wurde untersucht. Eine leichte Difluorierung fand statt mit Carbanionen vom Typus CH (C=X)₂. Mechanismen für die verschiedenen Heterolysen von PF werden vorgeschlagen.     

Age differences in the cellular response to cerebral lesions in the dog and mouse

Zusammenfassung Die zelluläre Reaktion an traumatischen, mechanisch gesetzten Läsionen in der Gehirnrinde wurde an neugeborenen und erwachsenen Hunden sowie an Mäusen untersucht. Die Heilung der Läsionen in Neugeborenen war so, dass das Gehirngewebe makroskopisch normal aussah; histologisch waren die durchtrennten Elemente durch die Heilungsprozesse unter minimaler glialer Reaktion wieder gut reorganisiert.     

Rapid Manufacturing of Non-Assembly Complex Micro-Devices by Microstereolithography

This paper introduces a non-assembly manufacturing case with microstereolithography technology. The design and manufacturing process of a pneumatic thrust bearing is described, and a special tessellation method is developed to further improve the capability of the manufacturing system thus bigger products can also be easily manufactured. Implemented in a layer-by-layer fashion, stereolithography has been used for the rapid manufacturing of complex devices, and it avoids the expensive assembly process in the traditional manufacturing. This paper presents that microstereolithography can produce high-resolution products with intricate details, small openings, and smooth surfaces. The potential of the microstereolithograhy technique is explored for the rapid manufacturing of small and complex objects.     

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. Here we report the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P < 5 × 10(-8) in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9 that show strong association across all our datasets (P < 5 × 10(-6) overall, with support in each of the three datasets studied). We also show that polymorphisms of ERAP1, which encodes an endoplasmic reticulum aminopeptidase involved in peptide trimming before HLA class I presentation, only affect ankylosing spondylitis risk in HLA-B27-positive individuals. These findings provide strong evidence that HLA-B27 operates in ankylosing spondylitis through a mechanism involving aberrant processing of antigenic peptides.