全文获取类型
收费全文 | 107篇 |
免费 | 0篇 |
国内免费 | 1篇 |
专业分类
现状及发展 | 40篇 |
研究方法 | 8篇 |
综合类 | 58篇 |
自然研究 | 2篇 |
出版年
2017年 | 1篇 |
2014年 | 2篇 |
2013年 | 1篇 |
2012年 | 1篇 |
2011年 | 7篇 |
2009年 | 1篇 |
2008年 | 4篇 |
2007年 | 5篇 |
2006年 | 1篇 |
2005年 | 6篇 |
2003年 | 5篇 |
2002年 | 3篇 |
2001年 | 5篇 |
2000年 | 5篇 |
1999年 | 3篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1990年 | 5篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 9篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1983年 | 3篇 |
1982年 | 1篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 3篇 |
1973年 | 2篇 |
1970年 | 2篇 |
1969年 | 2篇 |
1968年 | 1篇 |
1959年 | 1篇 |
排序方式: 共有108条查询结果,搜索用时 1 毫秒
1.
2.
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. 总被引:226,自引:0,他引:226
L A Donehower M Harvey B L Slagle M J McArthur C A Montgomery J S Butel A Bradley 《Nature》1992,356(6366):215-221
Mutations in the p53 tumour-suppressor gene are the most frequently observed genetic lesions in human cancers. To investigate the role of the p53 gene in mammalian development and tumorigenesis, a null mutation was introduced into the gene by homologous recombination in murine embryonic stem cells. Mice homozygous for the null allele appear normal but are prone to the spontaneous development of a variety of neoplasms by 6 months of age. These observations indicate that a normal p53 gene is dispensable for embryonic development, that its absence predisposes the animal to neoplastic disease, and that an oncogenic mutant form of p53 is not obligatory for the genesis of many types of tumours. 相似文献
3.
Harvey R. Brown Wayne Myrvold Jos Uffink 《Studies in History and Philosophy of Science Part B: Studies in History and Philosophy of Modern Physics》2009,40(2):174-191
A comparison is made of the traditional Loschmidt (reversibility) and Zermelo (recurrence) objections to Boltzmann's H-theorem, and its simplified variant in the Ehrenfests’ 1912 wind-tree model. The little-cited 1896 (measure-theoretic) objection of Zermelo (similar to an 1889 argument due to Poincaré) is also analysed. Significant differences between the objections are highlighted, and several old and modern misconceptions concerning both them and the H-theorem are clarified. We give particular emphasis to the radical nature of Poincaré's and Zermelo's attack, and the importance of the shift in Boltzmann's thinking in response to the objections taken together. 相似文献
4.
The strength of network biology lies in its ability to derive cell biological information without a priori mechanistic or molecular knowledge. It is shown here how a careful understanding of a given biological pathway can refine an interactome approach. This permits the elucidation of additional design principles and of spatio-temporal dynamics behind pathways, and aids in experimental design and interpretation. 相似文献
5.
6.
Lepidomeda albivallis (White River spinedace), a fish species endemic to the White River, Nevada, appeared headed toward extinction. In 1991 only 1 population remained, and it comprised fewer than 50 individuals in a 70-m stream reach. We monitored population recruitment and distribution and studied life history and habitat use from 1993 through 1998. We determined that L. albivallis was not reproducing and was continuing to decline, and as an emergency measure we relocated the population (14 in spring 1995 and 6 in spring 1996) downstream 200 m to a secure habitat that we judged more favorable for reproduction. The relocated population reproduced, and by September 1998 it had increased to 396 individuals that inhabited more than 1 km of stream including both pond and stream habitats. In streams they oriented near the bottom but frequently moved up in the water column to strike at drift items. Gut analysis of museum specimens indicated L. albivallis is omnivorous but feeds primarily upon aquatic invertebrates. Conservation of L. albivallis will require reestablishing additional populations within its former range. 相似文献
7.
Harvey I. Blau 《湖北大学学报(自然科学版)》1994,(2)
综述了C—代数,table代数的基本概念、发展历史,并报告了若干新发展,新结果。本文源于作者在1993年10月25~29日湖北大学群论研讨会上的几个系列报告。 相似文献
8.
M. V. Novotny T. -M. Xie S. Harvey D. Wiesler B. Jemiolo M. Carmack 《Cellular and molecular life sciences : CMLS》1995,51(7):738-743
Two male mouse pheromones, 3,4-dehydro-exo-brevicomin (DHB) and 2-sec-butyldihydrothiazole (SBT), are chiral molecules which were previously tested in their respective bioasays as racemic mixtures. The focus of this study has been to determine the absolute configuration of their natural forms and its relation to stereospecific biological action. DHB was established as the R,R-enantiomer possessing biological activity. Due to an extremely easy racemization of SBT under very mild conditions, enantioselectivity of its transmission and its action at the receptor site appear to be of secondary importance. 相似文献
9.
10.