排序方式: 共有5条查询结果,搜索用时 0 毫秒
1
1.
S. Benvenuti A. Gagliardo T. Guilford P. Luschi 《Cellular and molecular life sciences : CMLS》1996,52(6):608-612
In order to investigate the pigeon's compass mechanism, a series of overcast tests with clock-shifted birds were run at two familiar release sites. While controls were able to assume a correct homeward direction, the experimental birds' initial orientation cannot be explained either on the basis of a time-compensated sun compass or of a time-independent magnetic compass. Speculative explanations of our paradoxical results are attempted. 相似文献
2.
Summary An immunogen was prepared consisting of iodinated and thyroxylated bovine thyroglobulin which on theoretical and practical grouds was highly specific for thyroxine; a rabbit antiserum derived from it fell within limits for RIA specification under conditions wherein a T4-BSA immunogen product was inactive. 相似文献
3.
The inherited susceptibility to cancer 总被引:1,自引:0,他引:1
Guilford P 《Cellular and molecular life sciences : CMLS》2000,57(4):589-603
The study of inherited cancer syndromes has led to the identification of over 25 genes directly involved in tumorigenesis. These genes have functions as diverse as signal transduction, cell cycle control, cell-to-cell adhesion, control of apoptosis, DNA repair and the maintenance of genome stability. Most cancer syndromes have a dominant pattern of inheritance, due to germline loss-of-function mutation of a tumour suppressor gene. All the recessively inherited genes have been implicated in the maintenance of genome stability. This review summarises our current understanding of the functions of the major cancer susceptibility genes. 相似文献
4.
Grady WM Willis J Guilford PJ Dunbier AK Toro TT Lynch H Wiesner G Ferguson K Eng C Park JG Kim SJ Markowitz S 《Nature genetics》2000,24(1):16-17
Aberrant promoter methylation and the associated loss of gene expression is a common accompaniment of human cancers. Nonetheless, it has been challenging to demonstrate in any given tumour that methylation of a specific gene was causal and not consequent to malignant transformation. In this regard, our attention was drawn to the genesis of gastric cancers in individuals with hereditary diffuse gastric cancer (HDGC). These individuals harbour germline mutations in the gene encoding E-cadherin, CDH1, but their cancers have consistently demonstrated absence of loss of heterozygosity at the CDH1 locus. These findings suggested the hypothesis that CDH1 promoter methylation might function as the 'second genetic hit' in the genesis of these cancers. 相似文献
5.
1