The Ontological Constitution of Bounding-Judging in the Phenomenological Epistemology of von Bertalanffy's General System Theory

An analysis of the current presentation of boundary judgments in the Critical Systems literature highlights a general result: that the activity of bounding has been, implicitly or explicitly, considered as an epistemological issue. By arguing that knowledge is not produced singularly by bounding, the paper informs this general result. This, in turn, informs other results, which have emerged in current understanding. In particular, the paper argues (a) the reason why knowledge indeed never attains the status of "objective or right" knowledge, (b) how critique is dependent on some positing of knowledge, and (c) the exact place where critique is actioned. von Bertalanffy's attempted systems epistemology is considered at length because it explains and informs the epistemological conclusions seen to have been drawn in the current Critical Systems literature. von Bertalanffy's attempt requires the support of Husserlian phenomenology, especially Sartre's understanding of it. This requires an in-depth discussion of the phenomenological understanding of consciousness. Since the conclusions stem from von Bertalanffy, the paper reconsiders the status of General System Theory in Critical Systems Thinking.     

The Ontological Status of Critique

Two previous papers by the author are summarized in order to provide the context for the arguments and results of the present paper. The author's previous research has identified the exact place where critique is epistemologically actioned and this enables the present paper to argue for the attribution of ontological status to critique. Since it is commonly acknowledged that a lack of critique results in dogmatism or bounded rationality, these latter two are investigated—in greater depth than previously considered in the literature—and, though they are shown to be inescapable, they provide a route toward a fundamental principle which systemically brings together ontological, epistemological, ethical, and emancipatory concerns. The principle can be stated as follows: One is more or less emancipated depending upon the extent to which one is aware of critique-bounded emancipation as an ontological necessity and thus to the degree to which one ceases to attempt escaping from practical critique into the realms of dogmatic emancipation and rationally bounded emancipation. The paper provides accurate definitions of critique and emancipation, showing that one cannot be considered without the other, thus framing the manner in which further discussion of these two intimately related issues can be continued. In keeping with the author's previous published research, the relevance of von Bertalanffy's deliberations to Critical Systems Thinking, as well as Sartre's philosophy to systems thinking in general, is upheld.     

Bacteriophage T4 mutants which propagate on E. coli K12 but not on E. coli B

Summary We have isolated and characterized 2 mutants of coliphage T4 which are able to propagate on E. coli K12 but not on E. coli B. We have assigned the mutations to genes 8 and 53, both structural genes. The products of genes 8 and 53 are found in the baseplate.Supported by grant No 3.519.75 from the Fonds national Suisse de la Recherche Scientifique.     

Groundwork of a Sartrean Input Toward Informing Some Concerns of Critical Systems Thinking

Research under way by this author seeks to return to von Bertalanffy's philosophical deliberations believing that they can provide an input which is as yet untapped and which provides a journey through phenomenological and existential ideas. The motivation for the research stems from three interlinked areas. First, in examining the beginnings of Critical Systems Thinking, a justification is found for its embrace of diverse inputs which began with Critical Theory and Habermas. A main conclusion is that any diversity must have one thing in common: it must not violate systemicity. This leads to an examination of the initial Habermasian incorporation, where one finds that a question which directly leads Critical Systems Thinking to consider critical awareness, social awareness, and human emancipation remains unanswered. An answer is provided, but this answer comes from an as yet untapped source in the field, the work of Jean-Paul Sartre. The appearance of Sartre in providing what is deemed to be an important answer begs the further question of whether he can inform Critical Systems Thinking without violating systemicity. A return to von Bertalanffy, in the third section, shows that no such violation is pending since a reading of his philosophical deliberations paves the way for an input from Sartre, first through the phenomenological tradition and then through its existential variant. In the process, the systemic nature of both Sartre's approach and ethical concerns unfolds.     

Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2

A gene mutated in Charcot-Marie-Tooth disease type 4B (CMT4B), an autosomal recessive demyelinating neuropathy with myelin outfoldings, has been mapped on chromosome 11q22. Using a positional-cloning strategy, we identified in unrelated CMT4B patients mutations occurring in the gene MTMR2, encoding myotubularin-related protein-2, a dual specificity phosphatase (DSP).     

Managerial Effectiveness from a System Theoretical Point of View

This paper defines managerial effectiveness as the ability to answer three questions: (1) Given sparse knowledge of a problematic situation, how is it possible to extract information from it?; (2) If such information can indeed be extracted, how can it be structured in a way which enables rigorous problem definition?; and (3) If a problem can indeed be defined rigorously, how can this definition be used to inform a systemic approach toward resolution? Managerial effectiveness, in other words, is understood as the ability to make systemic decisions in the absence of clear facts. A configuration of Soft Systems Methodology (SSM) is presented, and it is argued that this configuration addresses the three questions and facilitates useful and practical systemic results in the face of partial information. Overall, the paper provides a theoretical basis for discussing managerial effectiveness, a decision making model which renders the theory operational, a teaching and training tool for disseminating SSM, and a blueprint from which to begin considering software support for the methodology.     

Modified Dye for Water-Fast Ink-Jet Printing

A quaternary ammonium compound containing amino acid residue was synthesized by Converting 3-chloro-2-hydroxy-propyalkyldimethylammonium chlorides into its epoxide derivatives, then attaching an amino acid to the epoxide derivatives synthesized a quaternary ammonium compound containing amino acid residue. Modified dyes were prepared by the ionotropy of anionic dyes with the quaternary ammonium compound containing amino acid residue. It was discovered that the modified dyes exhibited an excellent pH controllable solubility. These modified dyes have good water solubility at pH> 8.0, but they were water insoluble at pH < 6.5. On the printing paper, modified dyes in water-based ink-jet print ink could convert to water insoluble form and give prints excellent water fastness.