On the glutamine and γ-aminobutyric acid contents of various regions of the cat brain

Résumé Les auteurs ont déterminé par la méthode de la chromatographie à deux dimensions, la teneur en glutamine et en acide -aminobutyrique des différentes parties du cerveau du chat. La concentration la plus élevée de l'acide -aminobutyrique a été trouvé dans l'hypothalamus, tandis que celle de la glutamine a été constatée dans le noyau caudé. Les concentrations les plus basses de ces deux protéines apparaissent dans la substance blanche du cerveau.     

"数字地球"时代的我国西部可持续发展

“数字地球”作为新世纪信息时代的新目标和制高点,必将在西部大开发战略的实施过程中起到至关重要的作用。从“数字地球”的基本概念出发,应用“数字地球”的理论和技术,阐述了“数字地球”技术对西部大开发的战略意义和应用方向,为我国西部地区的可持续发展提供了新的思路和技术方法。     

Mechanisms of protein toxicity in neurodegenerative diseases

Protein toxicity can be defined as all the pathological changes that ensue from accumulation, mis-localization, and/or multimerization of disease-specific proteins. Most neurodegenerative diseases manifest protein toxicity as one of their key pathogenic mechanisms, the details of which remain unclear. By systematically deconstructing the nature of toxic proteins, we aim to elucidate and illuminate some of the key mechanisms of protein toxicity from which therapeutic insights may be drawn. In this review, we focus specifically on protein toxicity from the point of view of various cellular compartments such as the nucleus and the mitochondria. We also discuss the cell-to-cell propagation of toxic disease proteins that complicates the mechanistic understanding of the disease progression as well as the spatiotemporal point at which to therapeutically intervene. Finally, we discuss selective neuronal vulnerability, which still remains largely enigmatic.