Identification of the platelet ADP receptor targeted by antithrombotic drugs

Platelets have a crucial role in the maintenance of normal haemostasis, and perturbations of this system can lead to pathological thrombus formation and vascular occlusion, resulting in stroke, myocardial infarction and unstable angina. ADP released from damaged vessels and red blood cells induces platelet aggregation through activation of the integrin GPIIb-IIIa and subsequent binding of fibrinogen. ADP is also secreted from platelets on activation, providing positive feedback that potentiates the actions of many platelet activators. ADP mediates platelet aggregation through its action on two G-protein-coupled receptor subtypes. The P2Y1 receptor couples to Gq and mobilizes intracellular calcium ions to mediate platelet shape change and aggregation. The second ADP receptor required for aggregation (variously called P2Y(ADP), P2Y(AC), P2Ycyc or P2T(AC)) is coupled to the inhibition of adenylyl cyclase through Gi. The molecular identity of the Gi-linked receptor is still elusive, even though it is the target of efficacious antithrombotic agents, such as ticlopidine and clopidogrel and AR-C66096 (ref. 9). Here we describe the cloning of this receptor, designated P2Y12, and provide evidence that a patient with a bleeding disorder has a defect in this gene. Cloning of the P2Y12 receptor should facilitate the development of better antiplatelet agents to treat cardiovascular diseases.     

Computer-Aided Detection System on Tangled Roller

Introduction Intheposttreatmentofchoppedfibreproduction,the thirddraftingrollerandtensionheat settingrolleroftenwere tangledbybrokentowforthereasonofhighspeed,hightemperatureofrollersurface,orotheradditionalforeign factors.While,thetworollerswerekeysegmentinthewhole technology.Itwouldleadtooneormoredrumcavedin,and eventobediscardediftheequipmenthadnotbeenstoppedintime.Usually,suchaccidentwouldbringgreatloss,what wouldnotbegotback.Sothetotalsetofequipmentrequiredthatdetectormusthavegoodperfo…     

19世纪英、德两国教育中的民族性之比较

英国曾是世界上最强大的经济实体,自命日不落帝国.但进入20世纪后,英国却不可挽回地迅速衰退了.与此同时,德国在1871年统一之前还是长期陷于四分五裂和处于封建割据的国家,却在20世纪初成为一个后起的资本主义国家,经济实力超过英国,仅次于美国跃居世界第二位.本文就英国的衰落和德国的崛起,从其在文化教育中所体现出的民族特性进行浅析,并藉此对中国当前的教育改革和发展作点探索和思考.     

The occurrence of a band of nuclei in primary neural induction in the chick embryo

Résumé L'induction primaire du système nerveux est étudiée chez l'embryon normal de poulet. Un nouveau marqueur morphologique de cette induction est découvert dans l'ectoderme. Au moment de l'induction (étape –5), und bande de noyaux apparaît dans l'ectoderme en avant du nud de Hensen. Dan une autre série d'expériences, on a implanté un greffon de nud de Hensen dans un autre embryon. Une bande de noyaux est aussi apparue dans l'ectoderme du greffon 3 h plus tard et dans l'ectoderme de l'hôte, 6 à 8 h après l'opération.     

Primary neural induction as studied by scanning electron microscopy.

Normal primary neural induction has been studied by scanning electron microscopy and the results compared with those obtained by TEM. Mesoderm cells are usually in contact with several other cells, both mesodermal and endodermal in origin. By SEM the ectoderm layer has been shown to be in contact with the underlying mesoderm cells. Tufts of fibrous basement membrane are also present between the two cell types. TEM specimens also show an intermediate basement membrane.     

Plateau 'pop-up' in the great 1897 Assam earthquake

The great Assam earthquake of 12 June 1897 reduced to rubble all masonry buildings within a region of northeastern India roughly the size of England, and was felt over an area exceeding that of the great 1755 Lisbon earthquake. Hitherto it was believed that rupture occurred on a north-dipping Himalayan thrust fault propagating south of Bhutan. But here we show that the northern edge of the Shillong plateau rose violently by at least 11 m during the Assam earthquake, and that this was due to the rupture of a buried reverse fault approximately 110 km in length and dipping steeply away from the Himalaya. The stress drop implied by the rupture geometry and the prodigious fault slip of 18 +/- 7 m explains epicentral accelerations observed to exceed 1g vertically and surface velocities exceeding 3 m s-1 (ref. 1). This quantitative observation of active deformation of a 'pop-up' structure confirms that faults bounding such structures can penetrate the whole crust. Plateau uplift in the past 2-5 million years has caused the Indian plate to contract locally by 4 +/- 2 mm yr-1, reducing seismic risk in Bhutan but increasing the risk in northern Bangladesh.