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Zusammenfassung Chemisch synthetisiertes Galaktose-1,6-Diphosphat wird als Hemmer dès Glukose-1,6-Di-phosphats in der Phosphoglukomutase-Reaktion bestimmt. 相似文献
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Summary The proportion of purines and pyrimidines in the DNA of the Ehrlich mouse ascites carcinoma is examined and compared with the base proportion of the DNA from liver and kidney of the normal mouse. The following findings were obtained: The DNA of the ascites tumor contains more guanine and less cytosine and thymine than the DNA of the normal mouse. For guanine this difference is statistically significant. The changed base compound is discussed with regard to the changed growing rate in tumors and the altered chromosome structure in the Ehrlich ascites carcinoma.
Durchgeführt mit Unterstützung der Deutschen Forschungsgemeinschaft. 相似文献
Durchgeführt mit Unterstützung der Deutschen Forschungsgemeinschaft. 相似文献
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W. Kuhn G. Ebner H. J. Kuhn D. H. Walters 《Cellular and molecular life sciences : CMLS》1960,16(3):106-107
Summary Crosslinked foils of pure (commercial) polyvinylalcohol, swollen in an acetate-puffer (pH=5), in presence of 2-methylnaphtochinon 1,4 and platinum are found to act as redox-muscles contracting and dilating when treated with hydrogen and oxygen.Mechanical stretching of the filaments is associated with a shift of the redox-potential. 相似文献
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Summary About 60% of the prolactin receptors were solubilized from rabbit mammary gland membranes by Zwittergent 3–12. The use of Zwittergent 3–12 resulted in increased sensitivity of the receptor assay and permitted use of ovine prolactin instead of human growth hormone in the receptor assay.Acknowledgments. This work was supported by grant AM 17476 from the National Institutes of Health. 相似文献
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Lukas Trixl Thomas Amort Alexandra Wille Manuela Zinni Susanne Ebner Clara Hechenberger Felix Eichin Hanna Gabriel Ines Schoberleitner Anming Huang Paolo Piatti Roxana Nat Jakob Troppmair Alexandra Lusser 《Cellular and molecular life sciences : CMLS》2018,75(8):1483-1497
Chemical modifications of RNA have been attracting increasing interest because of their impact on RNA fate and function. Therefore, the characterization of enzymes catalyzing such modifications is of great importance. The RNA cytosine methyltransferase NSUN3 was recently shown to generate 5-methylcytosine in the anticodon loop of mitochondrial tRNAMet. Further oxidation of this position is required for normal mitochondrial translation and function in human somatic cells. Because embryonic stem cells (ESCs) are less dependent on oxidative phosphorylation than somatic cells, we examined the effects of catalytic inactivation of Nsun3 on self-renewal and differentiation potential of murine ESCs. We demonstrate that Nsun3-mutant cells show strongly reduced mt-tRNAMet methylation and formylation as well as reduced mitochondrial translation and respiration. Despite the lower dependence of ESCs on mitochondrial activity, proliferation of mutant cells was reduced, while pluripotency marker gene expression was not affected. By contrast, ESC differentiation was skewed towards the meso- and endoderm lineages at the expense of neuroectoderm. Wnt3 was overexpressed in early differentiating mutant embryoid bodies and in ESCs, suggesting that impaired mitochondrial function disturbs normal differentiation programs by interfering with cellular signalling pathways. Interestingly, basal levels of reactive oxygen species (ROS) were not altered in ESCs, but Nsun3 inactivation attenuated induction of mitochondrial ROS upon stress, which may affect gene expression programs upon differentiation. Our findings not only characterize Nsun3 as an important regulator of stem cell fate but also provide a model system to study the still incompletely understood interplay of mitochondrial function with stem cell pluripotency and differentiation. 相似文献
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Müller T Hess MW Schiefermeier N Pfaller K Ebner HL Heinz-Erian P Ponstingl H Partsch J Röllinghoff B Köhler H Berger T Lenhartz H Schlenck B Houwen RJ Taylor CJ Zoller H Lechner S Goulet O Utermann G Ruemmele FM Huber LA Janecke AR 《Nature genetics》2008,40(10):1163-1165
Following homozygosity mapping in a single kindred, we identified nonsense and missense mutations in MYO5B, encoding type Vb myosin motor protein, in individuals with microvillus inclusion disease (MVID). MVID is characterized by lack of microvilli on the surface of enterocytes and occurrence of intracellular vacuolar structures containing microvilli. In addition, mislocalization of transferrin receptor in MVID enterocytes suggests that MYO5B deficiency causes defective trafficking of apical and basolateral proteins in MVID. 相似文献
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Summary The inhibition of sarcolemmal Na, K, Mg ATPase from the guinea pig heart by ouabain was evaluated with a coupled enzyme assay. Models of negative cooperativity and of two independent receptors fitted the inhibition data equally well. The analysis was not compatible with a homogeneous population of non-interacting ouabain receptors.Acknowledgments. The technical assistance of P. Mayr and G. Ruhland is gratefully acknowledged. 相似文献
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Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8 总被引:7,自引:0,他引:7
Moseley ML Zu T Ikeda Y Gao W Mosemiller AK Daughters RS Chen G Weatherspoon MR Clark HB Ebner TJ Day JW Ranum LP 《Nature genetics》2006,38(7):758-769