基于改进 HAF的线性调频雷达信号参数估计

针对多项式相位信号(PPS)中的线性调频(LFM)雷达信号参数估计,通过提出频谱方差极大值准则对PPS次优参数估计方法高阶模糊度函数(HAF)进行了改进,提出了适于单分量LFM参数估计的改进HAF。首先讨论了HAF对LFM参数的估计方法及其局限性,然后提出了分段频谱方差极大值法则下LFM调频斜率估计的方法,将其与HAF相结合提出了单分量LFM参数估计的改进HAF,克服了接收信号与实际信号起点不一致性对HAF带来的影响,降低了由于HAF局限性带来的调频斜率估计误差,改善了HAF的累积误差效应。MATLAB仿真验证了改进方法较HAF的优越性。     

平面图形设计中符号学原理的应用

图形设计作为视觉传达设计中的一种符号设计现象,其成功所在,是能得以运用设计的符号学原理不断挖掘其深处的潜质,并与人们内心深处的情感相沟通。因此,应该对此进行研究与认识,发掘更多的符号特性,更准确的运用符号学原理来进行平面图形设计。     

Energetic landscape of alpha-lytic protease optimizes longevity through kinetic stability.

During the evolution of proteins the pressure to optimize biological activity is moderated by a need for efficient folding. For most proteins, this is accomplished through spontaneous folding to a thermodynamically stable and active native state. However, in the extracellular bacterial alpha-lytic protease (alphaLP) these two processes have become decoupled. The native state of alphaLP is thermodynamically unstable, and when denatured, requires millennia (t1/2 approximately 1,800 years) to refold. Folding is made possible by an attached folding catalyst, the pro-region, which is degraded on completion of folding, leaving alphaLP trapped in its native state by a large kinetic unfolding barrier (t1/2 approximately 1.2 years). alphaLP faces two very different folding landscapes: one in the presence of the pro-region controlling folding, and one in its absence restricting unfolding. Here we demonstrate that this separation of folding and unfolding pathways has removed constraints placed on the folding of thermodynamically stable proteins, and allowed the evolution of a native state having markedly reduced dynamic fluctuations. This, in turn, has led to a significant extension of the functional lifetime of alphaLP by the optimal suppression of proteolytic sensitivity.     

对抗体系的一种建模方法研究

首先,通过实例阐明了信息交互在效能涌现中所起的重要作用;其此,提出了“基于信息关联网的体系建模方法”,为研究信息交互过程中对抗体系的效能涌现机理提供了方法论意义上的支持;最后,基于上述体系建模方法,给出了一个具体的建模实例。     

基于图示评审技术的风险投资组合模型

运用系统论和GERT网络理论的思想及其原理,揭示了组合中各项目之间的组合规律,提出了风险投资组合的串联、并联和混联这3种不同的组合模式,构建了其风险与周期评估的组合GERT网络模型,为更加深入地理解与正确客观地把握风险投资状态提供了算法模型和理论依据。     

改进地区生产总值核算的对策

以晋城市的GDP核算工作为例,分析了地区性生产总值核算中存在的问题,并提出了改进地区生产总值核算的对策。     

C1 inhibitor hinge region mutations produce dysfunction by different mechanisms.

Heterozygosity for a mutant dysfunctional C1 inhibitor protein, a member of the serine proteinase inhibitor (serpin) superfamily, results in type II hereditary angioneurotic oedema. We identified a "hinge" region mutation in C1 inhibitor with a Val to Glu replacement at P14 Val-432. Recombinant C1 inhibitors P10 Ala-->Thr and P14Val-->Glu did not form stable complexes with fluid phase C1s or kallikrein. The P14 Val-->Glu mutant, however, was cleaved to a 96K form by C1s, while the P10 Ala-->Thr mutant was not. The recombinant P10 mutant also did not complex with C1s, kallikrein or beta-factor Xlla-Sepharose. The two mutations, therefore, result in dysfunction by different mechanisms: in one (P14 Val-->Glu), the inhibitor is converted to a substrate, while in the other (P10 Ala-->Thr), interaction with target protease is blocked.     

地震作用下高层建筑多重调谐质量阻尼器控制优化设计

通过多重调谐质量阻尼器(MTMD)系统参数的可能组合，得到了5种MTMD模型．基于结构受按振型——MTMD系统的力学模型，建立了设置这5种MTMD时结构的传递函数和动力放大系数统一表达式．于是5种MTMD的优化准则可统一定义为结构最大动力放大系数的最小值的最小化．基于MTMD的优化结果即最优频率间隔、最优平均阻尼比和最优调谐频率比，利用Wilson—θ法对一22层高层钢结构—MTMD系统进行了时程分析．分析中所用地震波分别为：EL—Centro地震波，Taft地震波，天津地震波和上海地震波．进而评价了5种MTMD的地震反应控制效果和冲程情况．研究表明，在高层钢结构建筑的MTMD地震反应控制中宜优先考虑MTMD(Ⅰ)和MTMD(Ⅴ)模型．     

A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)

Severe Acute Respiratory Syndrome (SARS) is a newly identified infectious disease[1—5]. The global outbreak of SARS has been threatening the health of people worldwide and has killed 353 people and infected more than 5462 in 27 countries, as reported by WHO on April 29, 2003 (http://www.who.int/csr/sarscountry/en). Although it has been recognized that a variant of virus from the family of coronavirus might be the candidate pathogen of SARS[1—5], its identity as the unique pathogen sti…     

P物质对GABAA受体介导电流的作用

应用全细胞膜片箝技术,在大鼠新鲜分离的背根神经节细胞上观察到:SP对GABA激活电流有调制作用。实验结果表明:多数受检的大鼠背根神经节神经元对SP(28/41,68.5％)和GABA(36/41,88.2％)敏感,100μmol/LSP和100μmol/L GABA激活内向电流的幅值分别为243.8±82.7pA(x±s,n=9)和1.76±0.48nA(x±s,n=13)。GABA与SP激活的内向电流明显不同,前者具有明显的去敏感现象。实验预加SP(0.001～1μmol/L)30s后再加GABA,则GABA激活电流的幅值明显减小,而且GABA激活电流减小的程度与预加SP的浓度呈量效依赖关系。SP主要抑制GABA激活电流的峰电流,对其稳态电流的抑制不明显。预加0.1μmol/L SP之后约4min左右,SP对GA-BA激活电流的抑制效率最大,为49.8±7.2％(x±s,n=7,P≤0.01),而预加SP 12min之后,SP才失去对GABA激活电流的抑制作用。