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Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture 总被引:35,自引:0,他引:35
Young LE Fernandes K McEvoy TG Butterwith SC Gutierrez CG Carolan C Broadbent PJ Robinson JJ Wilmut I Sinclair KD 《Nature genetics》2001,27(2):153-154
Manipulation or non-physiological embryo culture environments can lead to defective fetal programming in livestock. Our demonstration of reduced fetal methylation and expression of ovine IGF2R suggests pre-implantation embryo procedures may be vulnerable to epigenetic alterations in imprinted genes. This highlights the potential benefits of epigenetic diagnostic screening in developing embryo procedures. 相似文献
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