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使用在TCP/UDP协议进行网络通信,会涉及IP地址、端口号、套接字、TCP/UDP协议等网络通信概念,而且TCP传输和UDP传输的编程模式是不同的,对网络通信概念进行了封装,实现了一个网络通信透明传输服务系统,且TCP传输和UDP传输具有相同的编程模式.使用表明,用户无需了解网络通信概念,即可使用该系统进行通信编程,... 相似文献
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MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis 总被引：2，自引：0，他引：2
Eberhart JK He X Swartz ME Yan YL Song H Boling TC Kunerth AK Walker MB Kimmel CB Postlethwait JH 《Nature genetics》2008,40(3):290-298
Disruption of signaling pathways such as those mediated by sonic hedgehog (Shh) or platelet-derived growth factor (Pdgf) causes craniofacial abnormalities, including cleft palate. The role that microRNAs play in modulating palatogenesis, however, is completely unknown. We show that, in zebrafish, the microRNA Mirn140 negatively regulates Pdgf signaling during palatal development, and we provide a mechanism for how disruption of Pdgf signaling causes palatal clefting. The pdgf receptor alpha (pdgfra) 3' UTR contained a Mirn140 binding site functioning in the negative regulation of Pdgfra protein levels in vivo. pdgfra mutants and Mirn140-injected embryos shared a range of facial defects, including clefting of the crest-derived cartilages that develop in the roof of the larval mouth. Concomitantly, the oral ectoderm beneath where these cartilages develop lost pitx2 and shha expression. Mirn140 modulated Pdgf-mediated attraction of cranial neural crest cells to the oral ectoderm, where crest-derived signals were necessary for oral ectodermal gene expression. Mirn140 loss of function elevated Pdgfra protein levels, altered palatal shape and caused neural crest cells to accumulate around the optic stalk, a source of the ligand Pdgfaa. These results suggest that the conserved regulatory interactions of mirn140 and pdgfra define an ancient mechanism of palatogenesis, and they provide candidate genes for cleft palate. 相似文献
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Ferrimagnet is a kind of basic and important multi-sublattice magnet material. It has attracted more and more attention of physicists and mathematicians. Many results of solitons and numerical computations on this topic have appeared. In this article, the dynamic equation for an isotropic ferrimagnet with two non-equivalent sublattices is studied, existence of weak solutions in multi dimension case is proved through the penalized method, the uniqueness and smoothness of the solution in one dimension case are also obtained by the relation between this equation and hyperbolic equation. 相似文献
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＂十二五＂时期,我国将进入以创新促转型,以转型促发展的新阶段,面对促进经济转型、创新发展模式的艰巨任务,高校院所是我国开展创新科学研究的一支重要力量。近年来,随着高等教育事业的蓬勃发展,高校院所承担的科研项目和筹措的科技经费均呈现大幅度增长,科技经费已成为高校院所重要的资金来源之一。如何提高国家科技经费的使用率、更好发挥国家财政科技经费的引导作用,是我国提高科技创新能力的一个重要任务。为提高国家财政科技经费资金使用效益,确保科研工作健康发展,需高度重视、加强高校院所国家财政科技经费管理及对策研究。 相似文献
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重点讨论即用浆料的研制与推广中须重视的几个问题,阐述了基础原料、助剂、浆料配方的重要性和即用浆料的质量标准。 相似文献
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基于Delft3D软件建立了北戴河中海滩浴场海域的二维及三维潮流和波浪耦合数学模型,并用实测潮流和波浪资料进行模型验证.利用验证后的模型模拟人工水下沙坝引起的水动力环境变化.结果表明:由于工程海域附近的潮流作用较弱,因此潮流影响仅体现在沙坝周围;4座人工水下沙坝具有一定的消浪作用,并且消浪作用随入射波高的增加而增强;总体上看,人工水下沙坝的建造使浴场附近的水动力作用减弱,水动力环境朝着有助于海滩保护的方向发展. 相似文献
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In this paper, the frequency characteristics of Chinese whispered speech were investigated by a filter bank analysis. It was shown that the first and the third formants were more important than the other formants in the speaker identification of Chinese whispered speech. The experiment showed that the 800?1200 Hz and 2800?3200 Hz ranges were the most significant frequency ranges in discriminating the speaker. Based on this result, a new feature scale named whisper sensitive scale (WSS) was proposed to replace the common scale, Mel scale, and to extract the cepstral coefficient from whispered speech signal. Furthermore, a speaker identification system in whispered speech was presented based on the modified Hidden Markov Models integrating advantages of WSCC (the whisper sensitive cepstral coefficient) and LPCC. And the new system performed better in solving the problem of speaker identification of Chinese whispered speech than the traditional method. 相似文献
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Ferrimagnet is a kind of basic and important multi-sublattice magnet material. It has attracted more and more attention of physicists and mathematicians. Many results of solitons and numerical computations on this topic have appeared. In this article, the dynamic equation for an isotropic ferrimagnet with two non-equivalent sublattices is studied, existence of weak solutions in multi dimension case is proved through the penalized method, the uniqueness and smoothness of the solution in one dimension case are also obtained by the relation between this equation and hyperbolic equation. 相似文献